DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and ATP1A2

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_000693.1	Gene:	ATP1A2 / 477	HGNCID:	800	Length:	1020	Species:	Homo sapiens

Alignment Length:	1003	Identity:	633/1003 - (63%)
Similarity:	775/1003 - (77%)	Gaps:	6/1003 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NG----KEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTPQP 73
            ||    |:|:|::...||:|..|:||:.:|||..:.:.|.:.||:...|:..|..:|||.|||.|
Human    18 NGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKGLTNQRAQDVLARDGPNALTPPP 82

  Fly    74 PTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTGLFTYF 138
            .||:|:.|.:.:||||:||||.|:.|||:.|.||...:.||.:||||||:.|..:|||||.|:|:
Human    83 TTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAMEDEPSNDNLYLGVVLAAVVIVTGCFSYY 147

  Fly   139 QVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAHGLKVD 203
            |..|||.|||||||:|||.|.||||||...:.::|:|.||:||||.|||||||:||:.:||.|||
Human   148 QEAKSSKIMDSFKNMVPQQALVIREGEKMQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVD 212

  Fly   204 NSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAGLDD 268
            |||||||||||.||.||||||||||:|:.|||||.:|||.||:||||||.|||||||.||:||:.
Human   213 NSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEV 277

  Fly   269 VQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLVTVTVCL 333
            .::||:.||:.||:.||..|:.||:|||.:||.|||.:::||:|||||||||||||||.||||||
Human   278 GRTPIAMEIEHFIQLITGVAVFLGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCL 342

  Fly   334 TLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTTESFRGS 398
            ||||||||.|||||||||||||||||||||||||||||||||||||:|:|..|.|:||||...|:
Human   343 TLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGA 407

  Fly   399 HFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIGAFRQKH 463
            .|.....::.||...|.|||.|.||.||::|.|.|:|..|:|||:||||..|.....:...|.::
Human   408 TFDKRSPTWTALSRIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRN 472

  Fly   464 IKLTEIPFNSTEKYQVSVHEFNSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTLKLEFEE 528
            .|:.|||||||.|||:|:||...|....::.|||||||||||||||::||..:.|...::..|:.
Human   473 PKVAEIPFNSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDKEMQDAFQN 537

  Fly   529 AYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAVPDAVAK 593
            ||:|:||:|||||||..|.||..|:|..::|..|..|||.|.|.|:||:|:||||||||||||.|
Human   538 AYMELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAVGK 602

  Fly   594 CRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATAIVVHGGEL 656
            |||||::||||||||||||||||:.||||:  ..|.||||.:..:.:..::.|:|.|.||||.:|
Human   603 CRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPMSQVNPREAKACVVHGSDL 667

  Fly   657 REMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIGVAMG 721
            ::|.:|:||.::..|.|||||||||||||||||.|||:|.||||||||||||||||:||||:|||
Human   668 KDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMG 732

  Fly   722 ISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIFDIPL 786
            ||||||||||||||||||||||||.|:||||:||||||||||||||||:|||.|||.|:|.:|||
Human   733 ISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPL 797

  Fly   787 ALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGVIQTVAC 851
            .|||:.|||||:||||:||||||||.||||||.|.||:...|:|||::||.|||.|||:||.:..
Human   798 PLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNSQTDKLVNERLISMAYGQIGMIQALGG 862

  Fly   852 FFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFVSIVVTQ 916
            |||:|.|:||:||.||||.|||.|||.:.:.||||.|||||||.:|||:|:|..|.||.||||.|
Human   863 FFTYFVILAENGFLPSRLLGIRLDWDDRTMNDLEDSYGQEWTYEQRKVVEFTCHTAFFASIVVVQ 927

  Fly   917 VFDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWWIYAFPFG 981
            ..||:||||||||:.||||.|.:|.|.|:.|..:|..|.|.|.....||||.:|..||..|||:.
Human   928 WADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSYCPGMGVALRMYPLKVTWWFCAFPYS 992

  Fly   982 LLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            ||||.:||.|:.::||.||||||:||||
Human   993 LLIFIYDEVRKLILRRYPGGWVEKETYY 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	628/993 (63%)
		Cation_ATPase_N	29..102	CDD:214842	33/72 (46%)
		E1-E2_ATPase	123..354	CDD:278548	162/230 (70%)
		Cation_ATPase	416..509	CDD:289987	50/92 (54%)
		COG4087	<673..738	CDD:226572	59/64 (92%)
		Cation_ATPase_C	785..994	CDD:279079	128/208 (62%)
ATP1A2	NP_000693.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		5/12 (42%)
		ATPase-IIC_X-K	30..1020	CDD:273445	626/989 (63%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..231		16/18 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.930