DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and CG6230

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_609490.1	Gene:	CG6230 / 34546	FlyBaseID:	FBgn0027582	Length:	1225	Species:	Drosophila melanogaster

Alignment Length:	864	Identity:	182/864 - (21%)
Similarity:	313/864 - (36%)	Gaps:	276/864 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LSFVEAKLRLEINGPNILTPQPPTPK---------------------WIVFLKTMFGGFAILLWA 95
            |:|:..: |:::.|.|:|....|||.                     :.||.||.:      :|.
  Fly   132 LAFLTCR-RVKLPGANVLAKVVPTPNNGNSKIVPIRSSKLEDGSTQYYFVFQKTKY------VWN 189

  Fly    96 GSFLCF------VGYLIQ-------LQTQHE-----------------PPDDNLYLGIALTVLVI 130
            .....|      |..|:.       |:|:.:                 |....|::..|.....:
  Fly   190 EDRKTFRAVEFPVNGLLSTYSSSRGLETEEDIKRATQTYGNNEMEMVVPEFHELFIERATAPFFV 254

  Fly   131 VT---------------GLFTYFQV--HKSSSIMDSFKNL--------VPQYATVIREGEINTVT 170
            ..               .|||.|.:  .:.:.:....:|:        .|......|:.:...:.
  Fly   255 FQVFSVGLWCMDDYWYYSLFTLFMLIAFECTIVKQQLRNMSEIRKMGNKPYLIYAFRQNKWRHLG 319

  Fly   171 SDEIVKGDIVEVKFGDR---VPADIRILEAHGLKVDNSSLTGESEPQVRSTEFTHEN---PLETK 229
            |||::.||:|.:.....   ||.|:.||....: ||.|.|||||.|.::.:..:.:|   .::.:
  Fly   320 SDELLPGDLVSITRSQNDNIVPCDLVILRGSCI-VDESMLTGESVPLMKESLESLDNLDVEMDAE 383

  Fly   230 N-----LAFFSTNVL-------------EGTCRGVVIATGDSTVMGRI-------ANLAAGLDDV 269
            .     :.|..|.|:             :|.|.|.||.||.:|..|::       ||.|
  Fly   384 GDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQGKLLRTILFGANRA------ 442

  Fly   270 QSPISREIQLFIRFITIFAIILGLSFFAISLTLGYE---------FIDAVVFLIGIIVANVPEGL 325
             :..:.|...||.|:.:|| :...|:..:.   |.|         |::..:.|..||..::|..|
  Fly   443 -TENNVETFAFIAFLMVFA-VAAASYVWVK---GSEDPERNRYKLFLECTLILTSIIPPDLPIEL 502

  Fly   326 LVTVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESD 390
            .:.|...|....|...    .......:...|.....|.|||||||.          |.::||..
  Fly   503 TLAVNTSLIQLTKLFV----FCTEPFRIPFAGKVQICCFDKTGTLTT----------DNLMVEGI 553

  Fly   391 TTESFRGSHFKIEDKSFNALFMCAALCNSAEFKGG--------------------QDDI----PV 431
            ...:..|:...||....|.:.:.|...:.|....|                    .|.:    |.
  Fly   554 AGLAPNGACVPIEKAEGNTVQVLACCHSLALLDDGLVGDPLEKATLAAVDWTLTKMDSVIPKRPQ 618

  Fly   432 FK--KDVNGNASEAALLKFTETIFAGIGAFRQKHIKLTEIPFNSTEKYQVSVHEFNSSDGYFIVE 494
            ||  |.:......:||.:.  ::.||       |:    ||:::..|:              |..
  Fly   619 FKPLKIIQRYHFSSALKRM--SVLAG-------HL----IPYSNEVKH--------------IGA 656

  Fly   495 MKGAPERILDRCSTIIIQGLSVELTPTLKLEFEEAYLEMGGMGERV--LGFADL-------LLPM 550
            :|||||         :||.:..|    :..::|:.|||....|.||  ||..||       :..|
  Fly   657 VKGAPE---------VIQKMLRE----VPADYEKVYLEYARRGARVLALGIKDLGTLGAQRVREM 708

  Fly   551 SKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAVPDAVAKCRSAGVRVIMVTGDHPITAKAI 615
            .:..:..:            |.|.|.:.:..|.:......:.:...:..:|:|:|||.|:||..:
  Fly   709 KREEVECD------------LTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMITGDSPLTACHV 761

  Fly   616 ARSVG------IITTPTAEDIAKQRGVTVLDIDSRQATAIVVHGGELREMKAEELDAVIYYH--- 671
            ||.:.      ||.||..||  ::...:.:.||..|:..:....|      :::|..::..|
  Fly   762 ARELRFTRKKLIILTPPEED--RKNNWSWVSIDGDQSYELDTKPG------SKKLSHLLATHDLC 818

  Fly   672 -----------NE-----------IVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRA 714
                       |:           .|.||.:|:||.:::...::.|....:.|||.||..|||.|
  Fly   819 ITGEGLQYLQQNQPQYMRQLLPQITVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHA 883

  Fly   715 DIGVAMGISGSDVSKQAAD 733
            ::||:: ::.:.|.::..:
  Fly   884 NVGVSL-LTSAPVKRKRTE 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	182/864 (21%)
		Cation_ATPase_N	29..102	CDD:214842	15/76 (20%)
		E1-E2_ATPase	123..354	CDD:278548	62/295 (21%)
		Cation_ATPase	416..509	CDD:289987	21/118 (18%)
		COG4087	<673..738	CDD:226572	19/72 (26%)
		Cation_ATPase_C	785..994	CDD:279079
CG6230	NP_609490.1	P-ATPase-V	109..1193	CDD:273738	182/864 (21%)
		E1-E2_ATPase	310..515	CDD:278548	54/216 (25%)
		Cation_ATPase	<590..664	CDD:289987	19/109 (17%)
		COG4087	<850..901	CDD:226572	16/51 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438595
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840