DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JYalpha and ATP13A5

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_940907.2	Gene:	ATP13A5 / 344905	HGNCID:	31789	Length:	1218	Species:	Homo sapiens

Alignment Length:	953	Identity:	214/953 - (22%)
Similarity:	371/953 - (38%)	Gaps:	188/953 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPN----------MGLSFVEAKLRLEI 63
            |.|:...|.:| |:....|:|....|:   .|||    |.|          :||:..|.::|..:
Human   126 ELKLRCMEVQK-IRYVWNDLEKRFQKV---GLLE----DSNSCSDIHQTFGLGLTSEEQEVRRLV 182

  Fly    64 NGPNILTPQPPTPKWIVFLKT------MFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLG 122
            .|||.:..: ..|.|.:.:|.      :|..|.:.||...     ||              :...
Human   183 CGPNAIEVE-IQPIWKLLVKQVLNPFYVFQAFTLTLWLSQ-----GY--------------IEYS 227

  Fly   123 IALTVLVIVTGLFTYFQVHKSSSIMDSFKNLVP-----QYATVIREGEINTVTSDEIVKGDIVEV 182
            :|:.:|.:::.:.:.:.:.:.|.   ...|||.     |...::::..:..:.|..:|.|||:.:
Human   228 VAIIILTVISIVLSVYDLRQQSV---KLHNLVEDHNKVQVTIIVKDKGLEELESRLLVPGDILIL 289

  Fly   183 KFGDRVPADIRILEAHGLKVDNSSLTGESEPQVRSTEFTHENPLE---------TKNLAFFSTNV 238
            .....:|.|..:::. ...|:...|||||.|..::.....||.:.         .|::.|..|.|
Human   290 PGKFSLPCDAVLIDG-SCVVNEGMLTGESIPVTKTPLPQMENTMPWKCHSLEDYRKHVLFCGTEV 353

  Fly   239 L------EGTCRGVVIATGDSTVMGRIANLAAGLDDVQSPISREIQLF---IRFITIFAIILGLS 294
            :      :|..|.||:.||.:|..|.:..      .:..|.....:|:   .:|| :|...||:.
Human   354 IQVKPSGQGPVRAVVLQTGYNTAKGDLVR------SILYPRPLNFKLYSDAFKFI-VFLACLGVM 411

  Fly   295 --FFAISLTL--GYEFIDAVVFLIGIIVANVPEGLLVTVTVCLTLTAKRMASKNCLVKNLEAVET 355
              |:|:.:.:  |....|.|...:.::...||..|...:|:......||:..|.....:.:.:..
Human   412 GFFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINM 476

  Fly   356 LGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTTESFRGSHFKIEDKSFNALFMCAAL--CN 418
            .|..:.:|.|||||||::.:   .||  ..:..:|  ..|:.:|.....::.....:|||:  |:
Human   477 CGQINLVCFDKTGTLTEDGL---DLW--GTVPTAD--NCFQEAHSFASGQAVPWSPLCAAMASCH 534

  Fly   419 SAEFKGG--QDDIPVFKKDVNGNA--SEAALL---KF----TETIFAGIGAFR---QKHIKLTEI 469
            |.....|  |.| |:..|...|.|  .|..::   ||    :..|..|..|.:   :..|.|.:.
Human   535 SLILLNGTIQGD-PLDLKMFEGTAWKMEDCIVDSCKFGTSVSNIIKPGPKASKSPVEAIITLCQF 598

  Fly   470 PFNSTEKYQVSVHEFNSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTLKLEFEEAYLEMG 534
            ||:|:.: ::||....:.:.:|.|.||||||.:...|.           :.|:...|.:......
Human   599 PFSSSLQ-RMSVIAQLAGENHFHVYMKGAPEMVARFCR-----------SETVPKNFPQELRSYT 651

  Fly   535 GMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAVPDAVAKCRSAGV 599
            ..|.||:..|...|.|.........:.:...   ..|.||||:.:.:..:......:.:...|.:
Human   652 VQGFRVIALAHKTLKMGNLSEVEHLAREKVE---SELTFLGLLIMENRLKKETKLVLKELSEARI 713

  Fly   600 RVIMVTGDHPITAKAIARSVGIITTPTAEDIAKQRGVTVLDID---------------SRQATA- 648
            |.:|:|||:..||..:|::        :|.|.....|.:::.|               ..|.|.
Human   714 RTVMITGDNLQTAITVAKN--------SEMIPPGSQVIIVEADEPEEFVPASVTWQLVENQETGP 770

  Fly   649 ----IVVHGGELREMKAE-----------ELDAVIYYH----------NEIVFARTSPQQKLIIV 688
                |.:|.|.....:.|           :...||:.|          |..||||.||.||..::
Human   771 GKKEIYMHTGNSSTPRGEGGSCYHFAMSGKSYQVIFQHFNSLLPKILVNGTVFARMSPGQKSSLI 835

  Fly   689 EACQRRGEIVAVTGDGVNDSPALKRADIGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRI 753
            |..|:....|.:.|||.||..|||.|..|:::....:.|   |:.......|...:...|.|||.
Human   836 EEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASV---ASPFTSKTTNIQCVPHLIREGRA 897

  Fly   754 IFDNLKKSIAYTLTSNLPEIVPFLFFVIFDIPLAL-GTIAILCIDIGTDMLPAISLAYEKAESDI 817
            .   |..|........:..|:.|:..::....|.| |....|..|:...::..::::...|...:
Human   898 A---LVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLTMSSTHAYPKL 959

  Fly   818 MARMPRDPFEDRLVNKKLILMAYLQIGVIQTVACFFTFFAIMA 860
            ....|    ..:|::..|:|..:|.       :||.....|.|
Human   960 APYRP----AGQLLSPPLLLSIFLN-------SCFSCIVQISA 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	211/945 (22%)
		Cation_ATPase_N	29..102	CDD:214842	21/88 (24%)
		E1-E2_ATPase	123..354	CDD:278548	54/257 (21%)
		Cation_ATPase	416..509	CDD:289987	31/108 (29%)
		COG4087	<673..738	CDD:226572	23/64 (36%)
		Cation_ATPase_C	785..994	CDD:279079	15/77 (19%)
ATP13A5	NP_940907.2	P5-ATPase	17..137	CDD:289194	4/11 (36%)
		P-ATPase-V	18..1119	CDD:273738	214/953 (22%)
		Cation_ATPase_N	<170..239	CDD:279080	18/88 (20%)
		E1-E2_ATPase	228..471	CDD:278548	54/253 (21%)
		Cation_ATPase	<595..636	CDD:289987	15/52 (29%)
		COG4087	<822..>871	CDD:226572	21/48 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910