DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and Atp2b4

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	XP_038946574.1	Gene:	Atp2b4 / 29600	RGDID:	621305	Length:	1241	Species:	Rattus norvegicus

Alignment Length:	1104	Identity:	312/1104 - (28%)
Similarity:	478/1104 - (43%)	Gaps:	267/1104 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 HKIPVDELLERLKTDPNMGLSFVEAKL--RLEINGPNILTPQPPTPKWIVFLKTMFGGF------ 89
            |...|.|:..||||.|..|||...|.|  |..:.|.|::.|:.|.    .||:.::...
  Rat    47 HYGSVQEICARLKTSPVEGLSGNPADLEKRRLVFGKNMIPPKKPK----TFLELVWEALQDVTLI 107

  Fly    90 -----AILLWAGSF---------LCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTGLFTYFQV 140
                 ||:....||         :|  |:::....:.|..:.....|.|:...||:....|.|
  Rat   108 ILEIAAIISLVLSFYRPPGGENEIC--GHIVSNPEEDEEGETGWIEGAAILASVIIVVFVTAF-- 168

  Fly   141 HKSSSIMDSFKNL-----VPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAHGL 200
             ...|....|:.|     :.|..::||.|::..:...|||.|||.:||:||.:|||..:::.:.|
  Rat   169 -NDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGDLLPADGILIQGNDL 232

  Fly   201 KVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAG 265
            |:|.|||||||: .|:.|       |:...:....|:|:||:.|.||.|.|.::..|.|..|...
  Rat   233 KIDESSLTGESD-HVKKT-------LDKDPMLLSGTHVMEGSGRMVVTAVGINSQTGIIFTLLGA 289

  Fly   266 LDD----------------------VQSPISREIQ--------------------------LFIR 282
            .::                      .|..::.|||                          :...
  Rat   290 NEEEDDEKKKKGKKQGVSENRNKAKTQDGVALEIQPLNSQEGLDSEEKEKKASKGPKKEKSVLQG 354

  Fly   283 FITIFAIILG-----LSFFAISLTLGYEFIDAVV---------------------FLIG--IIVA 319
            .:|..|:.:|     :|...:.:.:.|..:|..|                     |:||  ::|.
  Rat   355 KLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQRRAWLPECTPVYIQYFVKFFIIGVTVLVV 419

  Fly   320 NVPEGLLVTVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQ 384
            .|||||.:.||:.|..:.|:|...|.||::|:|.||:|:.:.||||||||||.|||||...:
  Rat   420 AVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAY--- 481

  Fly   385 IIVESDTTESFRGSHF----KIEDKSFNAL-FMCAALC-NSA--------EFKGGQDDIPVFKKD 435
                      ..|:|:    |.:|...|.| .:..::| |||        |.:||   :|   :.
  Rat   482 ----------IGGTHYRQIPKPDDLPPNVLDLIVNSICINSAYTSKILPPEKEGG---LP---RQ 530

  Fly   436 VNGNASEAALLKFTETIFAGIGAFRQK--HIKLTEI-PFNSTEKYQVSVHEFNSSDGYFIVEMKG 497
            | ||.:|..||.|...:.....|.|.:  ..||.:: .|||..|...:|  ....:|.|.|..||
  Rat   531 V-GNKTECGLLGFVTDLKQDYQAVRSEMPEEKLFKVYTFNSVRKSMSTV--IRKPEGGFRVFSKG 592

  Fly   498 APERILDRCSTIIIQ--GLSVELTPTLKLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISY-EF 559
            |.|.:|.:|..|:.:  |:....|.............|...|.|.:|            |:| :|
  Rat   593 ASEIMLRKCDRILNKEGGIVPFKTKDRDNMVRNVIEPMASEGLRTIG------------IAYRDF 645

  Fly   560 SADPPNFPLENLRFLGLISLI-----DPPRAAVPDAVAKCRSAGVRVIMVTGDHPITAKAIARSV 619
            ..:.|::..||..|.||:.:.     ||.|..||||:.||:.||:.|.|||||:..||:|||...
  Rat   646 DGEEPSWENENEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTARAIATKC 710

  Fly   620 GIITTPTAEDIAKQRGVTVLDIDSRQATAIVVHGGELREMKAEELDAVIYYHNEIVFARTSPQQK 684
            ||:|.          |...|.::.::...::  ..|..|::.|:||.|  :....|.||:||..|
  Rat   711 GILTP----------GDDFLCLEGKEFNRLI--RNEKGEVEQEKLDKV--WPRLRVLARSSPTDK 761

  Fly   685 LIIVEAC-------QRRGEIVAVTGDGVNDSPALKRADIGVAMGISGSDVSKQAADMILLDDNFA 742
            ..:|:..       ||  ::|||||||.||.||||:||:|.||||:|:||:|:|:|:||.||||.
  Rat   762 HTLVKGIIDSNIGEQR--QVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFT 824

  Fly   743 SIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIF-------DIPLALGTIAILCIDIGT 800
            |||..:..||.::|::.|.:.:.||.|:..::     |.|       |.||.  .:.:|.:::..
  Rat   825 SIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI-----VAFSGACITQDSPLK--AVQMLWVNLIM 882

  Fly   801 DMLPAISLAYEKAESDIMARMP---RDPFEDRLVNKKLILMAYLQIGVIQTVACFFTFFAIMAEH 862
            |...:::||.|.....::.|.|   ..|...|.:.|.::..|..|:|::     |...||  .:.
  Rat   883 DTFASLALATEPPTDSLLRRRPYGRNKPLISRTMMKNILGHAVYQLGIV-----FLLVFA--GDK 940

  Fly   863 GFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFVSIVVTQVFDLLICKTRR 927
            .|          |.||.....|.....|.:|.             .|.:.|:.|:|:.:
  Rat   941 LF----------DIDSGRKAPLNSPPSQHYTI-------------VFNTFVLMQLFNEI------ 976

  Fly   928 NSILQQGMGNHVLNFALVLEFIIAC------LLCYVPVFE---KTLRMYSIKFIWWIYAFPFGL 982
            ||....|..|   .||.|...||.|      ..|.:.:.|   |.....::....|::....|:
  Rat   977 NSRKIHGEKN---VFAGVYRNIIFCSVVLGTFFCQILIVEVGGKPFSCTNLTMEQWMWCLFIGI 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	312/1104 (28%)
		Cation_ATPase_N	29..102	CDD:214842	25/90 (28%)
		E1-E2_ATPase	123..354	CDD:278548	80/311 (26%)
		Cation_ATPase	416..509	CDD:289987	33/104 (32%)
		COG4087	<673..738	CDD:226572	37/71 (52%)
		Cation_ATPase_C	785..994	CDD:279079	44/210 (21%)
Atp2b4	XP_038946574.1	ATPase-IIB_Ca	16..1052	CDD:273668	312/1104 (28%)
Atp2b4	XP_038946574.1	ATP_Ca_trans_C	1089..1172	CDD:403580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010