DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and Atp1a4

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_001257959.1	Gene:	Atp1a4 / 29132	RGDID:	61952	Length:	1028	Species:	Rattus norvegicus

Alignment Length:	1007	Identity:	614/1007 - (60%)
Similarity:	768/1007 - (76%)	Gaps:	7/1007 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NKEHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTP 71
            |::.|:  |.:|||::..||:|..|:||:.:|||..:...|...|||..:|:..|.:||||:|||
  Rat    25 NRQPKV--KRRKKDLEELKKEVVMDDHKLTLDELSAKYSVDLTKGLSVTDAQEILTLNGPNVLTP 87

  Fly    72 QPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPD-DNLYLGIALTVLVIVTGLF 135
            .|.||:||.|.|.:||||::|||.||.|||:.|.|.:....|..: |||||||.|:.:||:||.|
  Rat    88 PPTTPEWIKFCKQLFGGFSLLLWTGSLLCFLAYGIHVSYYQENANKDNLYLGIVLSAVVIITGCF 152

  Fly   136 TYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAHGL 200
            :|:|..|||.||:|||.:|||.|.|||:||...:...::|.||:||||.||:||||||::.|.|.
  Rat   153 SYYQEAKSSKIMESFKTMVPQQALVIRDGEKMQINVRDVVLGDLVEVKGGDQVPADIRVIAAQGC 217

  Fly   201 KVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAG 265
            ||||||||||||||.|..:.||||||||:|:.|||||.:|||.|||||||||.|||||||:|.:|
  Rat   218 KVDNSSLTGESEPQSRCPDCTHENPLETRNIIFFSTNCVEGTARGVVIATGDHTVMGRIASLTSG 282

  Fly   266 LDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLVTVT 330
            |...::||:.||:.||..||..|:.||::||.:||.|||.::|||:|||||||||||||||.|||
  Rat   283 LTMGKTPIATEIEHFIHIITAVAVFLGVTFFFLSLILGYTWLDAVIFLIGIIVANVPEGLLATVT 347

  Fly   331 VCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTT-ES 394
            |||||||||||.|||||||||||||||||||||||||||||||||||||||:|:.:.|:||: |.
  Rat   348 VCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWFDKTVYEADTSEEQ 412

  Fly   395 FRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIGAF 459
            ..|..|.....::..|...|.|||.|:||..|:.:|:.|:...|:|||:|||||.|..::.:...
  Rat   413 TTGKTFPKSSDTWFYLARIAGLCNRADFKPHQESLPITKRTTTGDASESALLKFIEQSYSPVSEM 477

  Fly   460 RQKHIKLTEIPFNSTEKYQVSVHEFNSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTLKL 524
            |||:.|:.|||||||.|||:|:|....:....::.||||||||||.||:.::.|....:...:|.
  Rat   478 RQKNPKVAEIPFNSTNKYQMSIHLLEDNSEAHVLLMKGAPERILDFCSSFLLNGQEYPMDEEMKT 542

  Fly   525 EFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAVPD 589
            :|:.||:|:||:|||||||..|.|| |.:...::|:.:..|||:|||.|.||||:|||||.||||
  Rat   543 DFQNAYIELGGLGERVLGFCFLNLP-SNFSKGFQFNTEELNFPMENLCFAGLISMIDPPRTAVPD 606

  Fly   590 AVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATAIVVH 652
            ||:||||||::||||||||||||||||:|||||:  ..||||||.:..:::..:.::...|||||
  Rat   607 AVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEANETAEDIAARLNISISQVSNKSIKAIVVH 671

  Fly   653 GGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIG 717
            |.||::|.:.:||.::..:.|||||||||||||||||.|||.|.||||||||||||||||:||||
  Rat   672 GSELKDMDSGQLDNILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIG 736

  Fly   718 VAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIF 782
            :||||:||||||||||||||||||||||.|:||||:||||||||||||||||:|||.|||.|::.
  Rat   737 IAMGITGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIVL 801

  Fly   783 DIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGVIQ 847
            .|||.||||.|||||:||||:||||||||..|||||.|:||:|..|.|||.:||.|||.|||:||
  Rat   802 SIPLPLGTITILCIDLGTDMVPAISLAYETPESDIMKRLPRNPKTDNLVNDRLIGMAYGQIGMIQ 866

  Fly   848 TVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFVSI 912
            .:|.|||:|.|:||:||.|..|.|||..||..|:.||||.|||:|||.:|||:|:|..|.||:||
  Rat   867 ALAGFFTYFVILAENGFKPLDLLGIRLYWDDTNLNDLEDTYGQQWTYEQRKVVEFTCQTAFFISI 931

  Fly   913 VVTQVFDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWWIYA 977
            |:.|..||:||||||||:.:|||.|.||.|.|:.|.|:|..|.|:|..:..||||.:|..||..|
  Rat   932 VIVQWADLIICKTRRNSLFKQGMKNKVLIFGLLEETILAACLSYIPGMDVALRMYPLKINWWFCA 996

  Fly   978 FPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            .|:.:|||.:||.|:.:|||.||||:|:||||
  Rat   997 LPYSVLIFIYDEVRKLIIRRRPGGWLEKETYY 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	609/995 (61%)
		Cation_ATPase_N	29..102	CDD:214842	37/72 (51%)
		E1-E2_ATPase	123..354	CDD:278548	154/230 (67%)
		Cation_ATPase	416..509	CDD:289987	47/92 (51%)
		COG4087	<673..738	CDD:226572	58/64 (91%)
		Cation_ATPase_C	785..994	CDD:279079	125/208 (60%)
Atp1a4	NP_001257959.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		4/12 (33%)
		ATPase-IIC_X-K	32..1028	CDD:273445	609/996 (61%)
		Cation_ATPase_N	46..119	CDD:214842	38/72 (53%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	87..89		1/1 (100%)
		E1-E2_ATPase	140..371	CDD:278548	154/230 (67%)
		Cation_ATPase	434..526	CDD:289987	46/91 (51%)
		COG4087	608..757	CDD:226572	103/148 (70%)
		Cation_ATPase_C	804..1013	CDD:279079	125/208 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930