DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and Atp1a4

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_038762.1	Gene:	Atp1a4 / 27222	MGIID:	1351335	Length:	1032	Species:	Mus musculus

Alignment Length:	1007	Identity:	610/1007 - (60%)
Similarity:	770/1007 - (76%)	Gaps:	7/1007 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NKEHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTP 71
            |::.|:  |.:|||::..||:|..|:||:.:|||..:...|...|||.:||:..|..||||:|||
Mouse    29 NRQPKM--KRRKKDLEELKKEVVMDDHKLTLDELSAKYSVDLTKGLSILEAQDILFQNGPNVLTP 91

  Fly    72 QPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPD-DNLYLGIALTVLVIVTGLF 135
            .|.||:|:.|.:.:||||::|||.|:.|||:.|.|.:....|..: |||||||.|:.:||:||.|
Mouse    92 PPTTPEWVKFCRQLFGGFSLLLWTGACLCFLAYGIHVNYYKENANKDNLYLGIVLSAVVIITGCF 156

  Fly   136 TYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAHGL 200
            :|:|..|||.||:||||:|||.|.|||:||...:...::|.||:||||.||::|||||::.|.|.
Mouse   157 SYYQEAKSSKIMESFKNMVPQQALVIRDGEKMQINVRDVVLGDLVEVKGGDQIPADIRVISAQGC 221

  Fly   201 KVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAG 265
            ||||||||||||||.|..:.||||||||:|:.|||||.:|||.||:||||||.|||||||:|.:|
Mouse   222 KVDNSSLTGESEPQSRCPDCTHENPLETRNIIFFSTNCVEGTARGIVIATGDYTVMGRIASLTSG 286

  Fly   266 LDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLVTVT 330
            |...::||:.||:.||..||..|:.||:|||.:|:.|||.::|||:|||||||||||||||.|||
Mouse   287 LQMGKTPIATEIEHFIHLITAVAVFLGVSFFWLSIILGYTWLDAVIFLIGIIVANVPEGLLATVT 351

  Fly   331 VCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTT-ES 394
            |||||||||||.|||||||||||||||||||||||||||||||||||||||:|:.:.|:||: |.
Mouse   352 VCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWFDKTVYEADTSEEQ 416

  Fly   395 FRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIGAF 459
            ..|..|.....::..|...|.|||.|:||..|:.:|:.|:...|:|||:|||||.|..:..:...
Mouse   417 TTGKTFPKSSDTWFYLARIAGLCNRADFKPHQESVPIAKRATTGDASESALLKFIEQSYNPVSEM 481

  Fly   460 RQKHIKLTEIPFNSTEKYQVSVHEFNSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTLKL 524
            |||:.|:.|||||||.|||:|:|....:....::.||||||||.|.||:.::.|....:...:|:
Mouse   482 RQKNPKVAEIPFNSTNKYQMSIHLLEDNSEAHVLLMKGAPERIFDFCSSFLLNGQEYPMDEEMKM 546

  Fly   525 EFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAVPD 589
            :|:.||:|:||:|||||||..|.|| |.:...::|:.|..|||:|||.|.||||:|||||.||||
Mouse   547 DFQNAYIELGGLGERVLGFCFLNLP-SNFSKGFQFNTDELNFPMENLCFAGLISMIDPPRTAVPD 610

  Fly   590 AVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATAIVVH 652
            ||:||||||::||||||||||||||||:|||||:  ..||||||.:..:.:..::::...|||||
Mouse   611 AVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNDTAEDIAARLNIPISQVNNKSVKAIVVH 675

  Fly   653 GGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIG 717
            |.||::|::::||.::..:.|||||||||||||||||.|||.|.||||||||||||||||:||||
Mouse   676 GSELKDMESQQLDDILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIG 740

  Fly   718 VAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIF 782
            :||||:||||||||||||||||||||||.|:||||:||||||||||||||||:|||.|||.|:|.
Mouse   741 IAMGITGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIL 805

  Fly   783 DIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGVIQ 847
            .|||.||||.|||||:||||:||||||||..|||||.|:||:|..|.|||.:||.|||.|||:||
Mouse   806 SIPLPLGTITILCIDLGTDMVPAISLAYESPESDIMKRLPRNPKTDNLVNNRLIGMAYGQIGMIQ 870

  Fly   848 TVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFVSI 912
            .:|.|||:|.|:||:||.|..|.|||..||...:.||||.|||:|||.:|||:|:|..|.||:||
Mouse   871 ALAGFFTYFVILAENGFKPLDLLGIRLYWDDTQLNDLEDSYGQQWTYEQRKVVEFTCQTAFFISI 935

  Fly   913 VVTQVFDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWWIYA 977
            |:.|..||:||||||||:.:|||.|.:|.|.|:.|.::|..|.|||..:.:||||.:|..||..|
Mouse   936 VIVQWADLIICKTRRNSLFKQGMKNKILIFGLLEETVLAAFLSYVPGMDVSLRMYPLKINWWFCA 1000

  Fly   978 FPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            .|:.:|||.:||.|:.:|||.||||:|:||||
Mouse  1001 LPYSVLIFVYDEIRKLIIRRRPGGWLEKETYY 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	605/995 (61%)
		Cation_ATPase_N	29..102	CDD:214842	35/72 (49%)
		E1-E2_ATPase	123..354	CDD:278548	153/230 (67%)
		Cation_ATPase	416..509	CDD:289987	46/92 (50%)
		COG4087	<673..738	CDD:226572	58/64 (91%)
		Cation_ATPase_C	785..994	CDD:279079	123/208 (59%)
Atp1a4	NP_038762.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		6/14 (43%)
		ATPase-IIC_X-K	36..1032	CDD:273445	605/996 (61%)
		Cation_ATPase_N	50..123	CDD:214842	36/72 (50%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	91..93		1/1 (100%)
		E1-E2_ATPase	144..375	CDD:278548	153/230 (67%)
		Cation_ATPase	438..530	CDD:289987	45/91 (49%)
		COG4087	<696..761	CDD:226572	58/64 (91%)
		Cation_ATPase_C	808..1017	CDD:279079	123/208 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920