DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and atp1a1a.5

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_835200.1	Gene:	atp1a1a.5 / 245703	ZFINID:	ZDB-GENE-020501-1	Length:	1023	Species:	Danio rerio

Alignment Length:	1010	Identity:	591/1010 - (58%)
Similarity:	751/1010 - (74%)	Gaps:	12/1010 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PKKKNKEHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPN 67
            |||        ||:.|||:...||:||.|:||:.::||..:..||...||....|...|..:|||
Zfish    23 PKK--------GKKNKKDMDELKKEVEMDDHKLTMEELSRKYGTDLTKGLPVSRAMEVLMRDGPN 79

  Fly    68 ILTPQPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVT 132
            .|||...||:|:.|.:.:||||..|||.|:|||:..:.||..|: ||.:|||||||.||.:|.|.
Zfish    80 ALTPPVITPEWVRFCRQLFGGFQTLLWIGAFLCYFAFSIQAATE-EPVNDNLYLGIVLTFVVTVN 143

  Fly   133 GLFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEA 197
            |.|:|.|..||..|||||||||||.|.|:|:||...:.::|:|.||:||||.||::||||||:.:
Zfish   144 GCFSYSQEAKSCRIMDSFKNLVPQKALVVRDGEKKIIDAEEVVVGDLVEVKGGDKIPADIRIVSS 208

  Fly   198 HGLKVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANL 262
            ||.||||||||||||||:|:.:.:.||||||:|:||||||.::|..||:|:.|||.|||||||:|
Zfish   209 HGCKVDNSSLTGESEPQIRTPDMSSENPLETRNIAFFSTNCIDGAARGIVVNTGDRTVMGRIASL 273

  Fly   263 AAGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLV 327
            |:.|:..|:|:.|||:.||..||..|:.||.:|..||:.||:.:::.::||||:|||||||||..
Zfish   274 ASNLEGGQTPLGREIEHFIHIITGVAVFLGTTFLIISVMLGFTWLEGIIFLIGLIVANVPEGLPC 338

  Fly   328 TVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTT 392
            ||||.||||||.||.|||||||||||||||||||||||||||||||||||||:|:|..|..:|||
Zfish   339 TVTVALTLTAKHMAKKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHIADTT 403

  Fly   393 ESFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIG 457
            |:..|:.|.....:::||...|.|||.|.|:..|..:||.:::..|:|||:||||..|.....:.
Zfish   404 ENQTGASFDRSSATWSALARVAGLCNRAVFQSNQSHLPVLRRETAGDASESALLKCIELCCGSVT 468

  Fly   458 AFRQKHIKLTEIPFNSTEKYQVSVHEF-NSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPT 521
            ..|:.:.|:.||||||..|||:|:||. |||:...::.|||||||||||||||:|:|....|...
Zfish   469 GMRENYPKVAEIPFNSISKYQLSIHENPNSSEPKHLLVMKGAPERILDRCSTILIEGKEHPLDDE 533

  Fly   522 LKLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAA 586
            :|.:|:.||:::||:|||||||....||..::|..:.|..:..|||.|||.|:||:|:|||||||
Zfish   534 MKEDFQNAYVQLGGLGERVLGFCHFCLPDDQFPEGFAFDTEEMNFPTENLCFVGLMSMIDPPRAA 598

  Fly   587 VPDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATAI 649
            ||||||||||||::||||||||||||||||:.||||:  ..|.:|||.:..:.:.:::.|.|.|.
Zfish   599 VPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVDDIAARLKIHIDEVNPRDAKAC 663

  Fly   650 VVHGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRA 714
            |:|||||:.|..|:||.|:.:|.|||||||||||||||||.|||:|.||||||||||||||||:|
Zfish   664 VIHGGELKNMTDEQLDDVLQHHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKA 728

  Fly   715 DIGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFF 779
            ||||||||:||||||||||||||||||||||.|:||||:|||||||||.|||::.:||:.|||.|
Zfish   729 DIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSICYTLSTKIPEMSPFLMF 793

  Fly   780 VIFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIG 844
            |:..|||.|||:.|||||:||||:||||.|||.||||||.|.||:...|||||::|:.::|.|||
Zfish   794 VLAGIPLPLGTVTILCIDLGTDMVPAISFAYENAESDIMKRQPRNAATDRLVNERLVSVSYGQIG 858

  Fly   845 VIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFF 909
            |:.....|||:|.|:||:||.|..|.|:|..|:.:...::||.|||:|||.:|||||||..|.:|
Zfish   859 VMNAFGGFFTYFVILAENGFLPWDLVGLRIGWNDRYFSEVEDSYGQQWTYEQRKVLEYTCHTAYF 923

  Fly   910 VSIVVTQVFDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWW 974
            .|||:.|...||:||:||.|:.:|||.|.||.|:|..|..||..|.|.|..:..:|||.:|.:||
Zfish   924 TSIVIMQWTTLLVCKSRRLSLAKQGMKNRVLTFSLFEETAIAAFLSYCPGMDIAVRMYPLKPMWW 988

  Fly   975 IYAFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            ..|||:.:|||.:||.|:..||:|||||||:||||
Zfish   989 FCAFPYMILIFIYDEVRKHFIRQNPGGWVERETYY 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	584/994 (59%)
		Cation_ATPase_N	29..102	CDD:214842	33/72 (46%)
		E1-E2_ATPase	123..354	CDD:278548	142/230 (62%)
		Cation_ATPase	416..509	CDD:289987	47/93 (51%)
		COG4087	<673..738	CDD:226572	59/64 (92%)
		Cation_ATPase_C	785..994	CDD:279079	112/208 (54%)
atp1a1a.5	NP_835200.1	ATPase-IIC_X-K	32..1023	CDD:273445	582/991 (59%)
		Cation_ATPase_N	41..115	CDD:214842	33/73 (45%)
		E1-E2_ATPase	134..365	CDD:278548	142/230 (62%)
		Cation_ATPase	427..521	CDD:289987	47/93 (51%)
		COG4087	603..752	CDD:226572	106/148 (72%)
		Cation_ATPase_C	799..1008	CDD:279079	112/208 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593931
Domainoid	1	1.000	87	1.000	Domainoid score	I7947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860