DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and Atp12a

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_619593.2	Gene:	Atp12a / 192113	MGIID:	1926943	Length:	1035	Species:	Mus musculus

Alignment Length:	1015	Identity:	549/1015 - (54%)
Similarity:	732/1015 - (72%)	Gaps:	11/1015 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKKNKEHKINGKEK-----KKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEI 63
            :|.:|:.| .||.|     |...:..||:::.|:|::...:|.::..|:...|||.:.|...|..
Mouse    23 QKDDKKFK-GGKNKDSEPNKSQEEELKKELDLDDHRLSNTDLEQKYGTNIIQGLSSIRAAELLAR 86

  Fly    64 NGPNILTPQPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVL 128
            :|||.|||...||:.|.|||.|.|||:||||.|:.||::.|:|| ........||:|||..|.::
Mouse    87 DGPNALTPPKQTPEIIKFLKQMVGGFSILLWIGAALCWIAYVIQ-YVSSTASLDNVYLGAILVLV 150

  Fly   129 VIVTGLFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIR 193
            ||:||:|.|:|..||::||.||..::||.|.|||:.|...:.::::|.||:||:|.||::|||||
Mouse   151 VILTGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKIIPAEQLVVGDVVEIKGGDQIPADIR 215

  Fly   194 ILEAHGLKVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGR 258
            ::.:.|.||||||||||||||.|||||||||||||||:.|:||..||||..|:||.|||.|::||
Mouse   216 LVFSQGCKVDNSSLTGESEPQARSTEFTHENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIGR 280

  Fly   259 IANLAAGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPE 323
            ||:||:|:...::||:.||:.|:..:...|:.:|:.||..::.:.|..:||::|||.||||||||
Mouse   281 IASLASGVGSEKTPIAIEIEHFVHIVAAVAVSVGVIFFITAVCMKYYVLDAIIFLISIIVANVPE 345

  Fly   324 GLLVTVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVE 388
            |||.||||.|:|||||||.||||||||||||||||||.||||||||||||||||||||:|..|..
Mouse   346 GLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFV 410

  Fly   389 SDTTESFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIF 453
            :||:|:.....|.....::.:|.....|||.|||:.||:.:|:.|:.|.|:|||.|||||:|.|.
Mouse   411 ADTSENQTKQAFDQSSGTWASLSKIITLCNRAEFRPGQESVPIMKRVVVGDASETALLKFSEVIL 475

  Fly   454 AGIGAFRQKHIKLTEIPFNSTEKYQVSVHEF-NSSDGYFIVEMKGAPERILDRCSTIIIQGLSVE 517
            ..:...|:::.|:.|||||||.|:|:|:||. :.:|..|::.|||||||||::||||:|.|....
Mouse   476 GDVMDIRKRNHKVAEIPFNSTNKFQLSIHETEDPNDKRFLMVMKGAPERILEKCSTIMINGQEQP 540

  Fly   518 LTPTLKLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDP 582
            |..:....|..||:|:||:|||||||..|.||..|:|.||.|..|..|||..||.|:||:|:|||
Mouse   541 LDKSSADAFHTAYMELGGLGERVLGFCHLYLPADKFPQSYTFDVDSINFPTSNLCFVGLLSMIDP 605

  Fly   583 PRAAVPDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQ 645
            ||:.|||||:||||||::||||||||||||||||:|||||:  ..|.|||||:|.:.|..::.|:
Mouse   606 PRSTVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANNETVEDIAKRRNIAVEQVNKRE 670

  Fly   646 ATAIVVHGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPA 710
            |.|.||.|.||::|..|:||.::..:.|||||||||||||||||.|||:..:|||||||||||||
Mouse   671 AKAAVVTGMELKDMTPEQLDELLINYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPA 735

  Fly   711 LKRADIGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVP 775
            ||:||||:||||:|||.:|.||||:||||||||||.|:||||:|||||||:||||||.|:.|:.|
Mouse   736 LKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTKNIAELCP 800

  Fly   776 FLFFVIFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAY 840
            ||.:::..:||.:|||.||.||:|||::|:|:|||||||||||.|.||...:||||||:|.:.:|
Mouse   801 FLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKKKDRLVNKQLAIYSY 865

  Fly   841 LQIGVIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAG 905
            |.||::|.:..|..:|.:.|:.||.|:.|..:|..|::.::.||||.||||||..:||.||:|..
Mouse   866 LHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRVSWETDDINDLEDSYGQEWTRYQRKYLEWTGS 930

  Fly   906 TGFFVSIVVTQVFDLLICKTRRNSILQQGM-GNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSI 969
            |.|||:|:|.|:.||:|.|||||||.|||: .|.|:...::.:.|:|.:|.|.......|....:
Mouse   931 TAFFVAIMVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGIISQIIVALVLSYGLGSVTALSFTML 995

  Fly   970 KFIWWIYAFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            :..:|..|.|..:||:.:||.|:..||..||.|.::..||
Mouse   996 RAQYWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	542/1000 (54%)
		Cation_ATPase_N	29..102	CDD:214842	32/72 (44%)
		E1-E2_ATPase	123..354	CDD:278548	133/230 (58%)
		Cation_ATPase	416..509	CDD:289987	49/93 (53%)
		COG4087	<673..738	CDD:226572	52/64 (81%)
		Cation_ATPase_C	785..994	CDD:279079	99/209 (47%)
Atp12a	NP_619593.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..49		7/26 (27%)
Atp12a	NP_619593.2	ATPase-IIC_X-K	40..1035	CDD:273445	541/995 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930