DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and catp-2

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_504328.1	Gene:	catp-2 / 182114	WormBaseID:	WBGene00015338	Length:	1050	Species:	Caenorhabditis elegans

Alignment Length:	1058	Identity:	378/1058 - (35%)
Similarity:	581/1058 - (54%)	Gaps:	92/1058 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KKNKEHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLK------TDPNM--GLSFVEAKLRL 61
            ::..|...:..:..|::......:..:.|.:.:.:|.|:..      .||.:  |||...|..||
Worm    12 RRGDEASDSKADASKEVNQQNLSLSFNEHHLDMRQLSEKFSMSKLDIVDPKVSRGLSKQVAAERL 76

  Fly    62 EINGPNILTPQPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPD-DNLYLGIAL 125
            |.:|.|.|:|......|.:||:.......||::..:.|..|.|:      ::|.| .||.:||.:
Worm    77 ESDGRNALSPPKVISNWKLFLRQFKNLLWILMFGAAALSLVAYI------YDPSDLTNLCVGIFI 135

  Fly   126 TVLVIVTGLFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPA 190
            .|::.|..:.::|:..|...::.:|::|:|....|||:|...|:..:|:|.||||.|:.|.:|||
Worm   136 IVIIFVMCIVSFFEEKKGVEVVRAFQSLMPLSCQVIRDGVEQTLNPEELVVGDIVVVRSGCKVPA 200

  Fly   191 DIRILEAHGLKVDNSSLTGESEPQVRSTEFTHENP--LETKNLAFFSTNVLEGTCRGVVIATGDS 253
            |||::......::.||:|||:||...::....:..  .|:.|:||..:..::|...|:||.||:.
Worm   201 DIRVIACTDFYLETSSITGEAEPLEFNSAMADQKTSIFESYNIAFNGSFCVDGEGYGIVIRTGER 265

  Fly   254 TVMGRIANLAAGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTL--GYEFIDAVV--FLI 314
            ||:|:||::.....:.:.....||..|::|||:.|||:.:..|::.|.:  |::.|...|  ||:
Worm   266 TVIGQIASMTLDQKEQKCKFQVEIGRFVKFITVMAIIMAVIIFSVGLGINKGHDVIRYFVTGFLM 330

  Fly   315 GIIVANVPEGLLVTVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAH 379
             :|:||||:||..|||..||:.|:|||.||..:|.||.::::|:|:.|.||||||||:|.|||..
Worm   331 -VIIANVPQGLPTTVTTELTIIARRMAKKNVFLKKLEKIDSVGATTLIASDKTGTLTKNCMTVTD 394

  Fly   380 LWYDQIIVESDTTESFRGS---HFKIED---KSFNA----LFMCAALCNSAEFKG---------- 424
            |||:. ...|...|:.|.|   .|.|..   :||:|    |.....:||.|..:.
Worm   395 LWYNN-SYNSGRPENRRRSTKTRFSITSNPAQSFDAPLSDLLSVVCVCNKARIENTVTVNRPPPN 458

  Fly   425 --GQDDI------PVFKKDVNGNASEAALLKFTETIFAGIGAFRQKHIKLTEIPFNSTEKYQV-- 479
              .:.|:      ||.:..:.||.||.|||::...:. .....|:....:.||||||..||.:
Worm   459 VDSELDMSMYRIQPVKEMTIVGNPSEVALLRYASAML-DAKELRESFQVVFEIPFNSVRKYHLIL 522

  Fly   480 --SVHEFN----SSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTLKLEFEEAYLEMGGMGE 538
              :.:.:|    :.|..|:|.:|||||.::..|||:.|.|.|.||......:|.|||...|..|.
Worm   523 ATNKNTWNQVDKNDDVEFVVMIKGAPEVLIKNCSTMNINGESKELDLKRMEDFNEAYEAFGDEGC 587

  Fly   539 RVLGFADLLLPMSKY--PISYEFSADPPNFPLENLRFLGLISLIDPPRAAVPDAVAKCRSAGVRV 601
            ||:|||     ..|:  ..|..||......|:|:..|||:.:::||||...|.|:..|::||::|
Worm   588 RVIGFA-----QKKFRARASTVFSLKSNTVPMEDWDFLGMSAIMDPPRDDTPKAIKACKAAGIKV 647

  Fly   602 IMVTGDHPITAKAIARSVGIITTPTAEDIAK-QRGVTVLDIDSRQATAIVVHGGELREMKAEELD 665
            .||||||..||.||||.:|:|.|   |:::: .....::...:.|..|::. |.||..:..::.|
Worm   648 YMVTGDHKSTATAIARQIGMIDT---EEVSRVDHNQQIIRRSNSQDWAVIT-GSELPALTQKQWD 708

  Fly   666 AVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIGVAMGISGSDVSKQ 730
            .:: .|..||||||:|:.||:||...|:|||.|.||||||||:||||:||:|||||::||||:||
Worm   709 ELL-QHRYIVFARTTPEHKLMIVTESQKRGECVTVTGDGVNDAPALKKADVGVAMGLAGSDVAKQ 772

  Fly   731 AADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIFDIPLALGTIAILC 795
            |||:|||||||:|||.||||||::||||:|:||||:....||:||.:....|..||.|..:.||.
Worm   773 AADIILLDDNFSSIVAGIEEGRLLFDNLRKTIAYTMAHMWPELVPVILNFFFGFPLGLTPVQILS 837

  Fly   796 IDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGVIQTVACFFTFFAIMA 860
            ||:.:|:.||:|||||..|:|||.:.||.. :..||.|.||...||.:.:..::.|...:.....
Worm   838 IDLISDIPPAVSLAYEGPEADIMLQPPRKK-DTHLVTKGLITYTYLFMSIFISIGCVCAYLLSYY 901

  Fly   861 EHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFVSIVVTQVFDLLICKT 925
            .:|..|..|......:......:.....|......::..:...|...|.:|:|:.|.|.|.:|.|
Worm   902 INGIGPWELAFTASTYFKHGAANFTTAKGVILNEEQQMYMANQAAAAFHISLVLGQAFHLWMCLT 966

  Fly   926 RRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFI-------W--WIYAFPFG 981
            ||.||...|:||.|..||::::.::.|:..:||         .:|:|       |  |:.....|
Worm   967 RRVSIFAHGLGNIVAIFAVIIDLLLICIFTFVP---------GVKYIFGSQPPPWQCWLVPIVVG 1022

  Fly   982 LLIFFFDESRRFLIRRNP 999
            :.|:.|:|.|:..||:.|
Worm  1023 VWIWIFNELRKLGIRKYP 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	377/1046 (36%)
		Cation_ATPase_N	29..102	CDD:214842	22/80 (28%)
		E1-E2_ATPase	123..354	CDD:278548	86/236 (36%)
		Cation_ATPase	416..509	CDD:289987	33/118 (28%)
		COG4087	<673..738	CDD:226572	46/64 (72%)
		Cation_ATPase_C	785..994	CDD:279079	64/217 (29%)
catp-2	NP_504328.1	HAD_like	66..1040	CDD:389748	370/1002 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860