DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and eat-6

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_506269.1	Gene:	eat-6 / 179796	WormBaseID:	WBGene00001137	Length:	996	Species:	Caenorhabditis elegans

Alignment Length:	997	Identity:	639/997 - (64%)
Similarity:	784/997 - (78%)	Gaps:	6/997 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTPQPPTPKWI 79
            |:||:::...|::|:.|.|.:|::||:.||.|:...||:..:|:..|..||||.|:|...||:||
Worm     4 KDKKQELHDLKQEVKMDEHIVPIEELVARLGTNLETGLTRQKAQEVLAKNGPNALSPPETTPEWI 68

  Fly    80 VFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTGLFTYFQVHKSS 144
            .|.|.:|||||:|||.|:.||::.|.:...|...|..|||||||.|..:|::||:|.|:|..|||
Worm    69 KFCKNLFGGFAMLLWVGAILCYIAYSVDYFTMEYPSKDNLYLGIVLMTVVVITGVFQYYQESKSS 133

  Fly   145 SIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAHGLKVDNSSLTG 209
            .|||||||:||.:|.|.|:|:...|.::|:|.|||||||.|||||||:|::.|.|.|||||||||
Worm   134 KIMDSFKNMVPTFALVHRDGQKQQVKTEELVVGDIVEVKGGDRVPADLRVVSAFGFKVDNSSLTG 198

  Fly   210 ESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAGLDDVQSPIS 274
            |||||.||.:.|:||||||:|:||||||.:|||.:|:||.|||:|||||||:||:|||...:||:
Worm   199 ESEPQSRSPDCTNENPLETRNIAFFSTNAVEGTAKGIVIYTGDNTVMGRIAHLASGLDTGMTPIA 263

  Fly   275 REIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLVTVTVCLTLTAKR 339
            |||:.||..||..|:.||:|||.|:..|||.::.|||||||||||||||||:.||||||||||||
Worm   264 REIEHFIHLITGVAVFLGISFFIIAFILGYHWLTAVVFLIGIIVANVPEGLIATVTVCLTLTAKR 328

  Fly   340 MASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTTESFRGSHFKIED 404
            ||||||||||||||||||||||||||||||||||||||||:|||:.|.|.||||: :.|..|...
Worm   329 MASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWYDETIHECDTTET-QTSQEKRTG 392

  Fly   405 KSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIGAFRQKHIKLTEI 469
            .||.||...|:|||.||||.||.|.|:.::|..|:|||.|||||||.....:.|.|:|:.|:.||
Worm   393 ASFEALVRIASLCNRAEFKAGQQDTPILRRDCTGDASEIALLKFTELTQGNVIAVREKNKKIAEI 457

  Fly   470 PFNSTEKYQVSVHEFNSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTLKLEFEEAYLEMG 534
            |||||.|||||:|:  :.|.|.:| ||||||||||.||||.:.|...|||..|:.:|..||||:|
Worm   458 PFNSTNKYQVSIHD--NGDHYLLV-MKGAPERILDVCSTIFLNGKESELTDKLREDFNTAYLELG 519

  Fly   535 GMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAVPDAVAKCRSAGV 599
            |||||||||.|.:||..|:|..::|..:..||||:||||:||:|:|||||||||||||||||||:
Worm   520 GMGERVLGFCDFVLPADKFPKGFKFDVEEVNFPLKNLRFVGLMSMIDPPRAAVPDAVAKCRSAGI 584

  Fly   600 RVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATAIVVHGGELREMKAE 662
            :|:||||||||||||||:|||||:  |.|.||||.:||:.|.:::.|:|.|.|:||.:||||..:
Worm   585 KVVMVTGDHPITAKAIAKSVGIISDGTETVEDIAIRRGIPVEEVNPREAKAAVIHGSDLREMSED 649

  Fly   663 ELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIGVAMGISGSDV 727
            :|..:|.||:|||||||||||||:|||..|::|:||||||||||||||||:|||||||||:||||
Worm   650 QLAEIIKYHSEIVFARTSPQQKLMIVEGFQKQGQIVAVTGDGVNDSPALKKADIGVAMGIAGSDV 714

  Fly   728 SKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIFDIPLALGTIA 792
            ||||||||||||||||||||:||||:||||||||||||||||:|||.|||.:::|.|||.|||:.
Worm   715 SKQAADMILLDDNFASIVVGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLTYILFGIPLPLGTVT 779

  Fly   793 ILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGVIQTVACFFTFFA 857
            |||||:||||:||||||||:||||||.|.||||..|:|||::||.:||.|||:||..|.|||:|.
Worm   780 ILCIDLGTDMVPAISLAYEEAESDIMKRQPRDPIRDKLVNERLISLAYGQIGMIQASAGFFTYFW 844

  Fly   858 IMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFVSIVVTQVFDLLI 922
            |||::||.|..|..:|..|||:...::.|.|||||||..||:||||..|.:||||||.|..||:|
Worm   845 IMADNGFMPWDLYQLRAQWDSRAYNNVLDSYGQEWTYANRKILEYTCQTAYFVSIVVVQWADLII 909

  Fly   923 CKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWWIYAFPFGLLIFFF 987
            .||||||::||||.|..|||.||.|..:|..:||.|..:..||||.::|.||..|.||.:|||.:
Worm   910 SKTRRNSLVQQGMSNWTLNFGLVFETALAWFMCYCPGLDNGLRMYGLRFSWWFCALPFSILIFVY 974

  Fly   988 DESRRFLIRRNPGGWVEQETYY 1009
            ||.|||||||.||||||:||||
Worm   975 DEIRRFLIRRYPGGWVERETYY 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	636/993 (64%)
		Cation_ATPase_N	29..102	CDD:214842	35/72 (49%)
		E1-E2_ATPase	123..354	CDD:278548	156/230 (68%)
		Cation_ATPase	416..509	CDD:289987	55/92 (60%)
		COG4087	<673..738	CDD:226572	56/64 (88%)
		Cation_ATPase_C	785..994	CDD:279079	125/208 (60%)
eat-6	NP_506269.1	ATPase-IIC_X-K	6..996	CDD:273445	636/993 (64%)
		Cation_ATPase_N	18..92	CDD:214842	35/73 (48%)
		E1-E2_ATPase	112..343	CDD:278548	156/230 (68%)
		Cation_ATPase	404..494	CDD:289987	55/92 (60%)
		COG4087	<644..725	CDD:226572	63/80 (79%)
		Cation_ATPase_C	772..981	CDD:279079	125/208 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I3526
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S851
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100215
Panther	1	1.100	-	-	O	PTHR43294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.880