DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and atp4a

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	XP_031762229.1	Gene:	atp4a / 100488221	XenbaseID:	XB-GENE-486104	Length:	1031	Species:	Xenopus tropicalis

Alignment Length:	1010	Identity:	540/1010 - (53%)
Similarity:	724/1010 - (71%)	Gaps:	9/1010 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKKNKEHKINGKEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNI 68
            |||:|     |.:|::.::|.||:::.::|:|.::||.::..|:...|:....|...|..:|||.
Frog    27 KKKSK-----GSKKQEKLESMKKEMDINDHEITIEELEQKYNTNVTKGMKATFAAEILIRDGPNE 86

  Fly    69 LTPQPPTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTG 133
            |.|...||:::.|.:.:.||...|:|..:.:|.:.:.|:.........|||||.|.|..:|:|||
Frog    87 LKPPKGTPEYVKFARQLAGGLQCLMWVAAVICLIAFGIECAQGDLTSADNLYLAITLIAVVVVTG 151

  Fly   134 LFTYFQVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAH 198
            .|.|:|..||::|:.||||||||.|||:|:||...:.::::|.||:||:|.||||||||||:.:.
Frog   152 CFGYYQEFKSTNIIASFKNLVPQQATVLRDGEKFQINANQLVVGDLVEIKGGDRVPADIRIITSQ 216

  Fly   199 GLKVDNSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLA 263
            |.||||||||||||||.||.|:|||:||||:|:|||||..||||..||:|.|||.|::||||:||
Frog   217 GCKVDNSSLTGESEPQTRSPEYTHESPLETRNIAFFSTMCLEGTATGVIINTGDRTIIGRIASLA 281

  Fly   264 AGLDDVQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLVT 328
            :|:.:.::||:.||:.|:..|...||..|.:||.:::.:||.|:.|:||.:.|:||.||||||.|
Frog   282 SGVGNEKTPIAIEIEHFVDIIAGLAIFFGATFFVVAMVIGYPFLRAMVFFMAIVVAYVPEGLLAT 346

  Fly   329 VTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTTE 393
            |||||:|||||:|.|||:||||||||||||||.||||||||||||||||:|||:|..|..:||||
Frog   347 VTVCLSLTAKRLARKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNQIHSADTTE 411

  Fly   394 SFRGSHFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIGA 458
            ...|..|.....::.||....:|||.|.||.|||.:|:.|:.|.|:|||.|||||:|.....:..
Frog   412 DQSGQSFDQTSDTWRALSKVTSLCNRACFKSGQDGVPIPKRIVIGDASETALLKFSELTVGNVME 476

  Fly   459 FRQKHIKLTEIPFNSTEKYQVSVHEFNSS-DGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTL 522
            :|.:..|.||:|||||.|:|:|:||.... |..:::.|||||||||:|||||:|:|..:.|....
Frog   477 YRDRFKKATELPFNSTNKFQLSIHELQDPLDLRYLLVMKGAPERILERCSTIMIKGQELPLDEQW 541

  Fly   523 KLEFEEAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAV 587
            |..|:.||:::||:|||||||..|.|...:||..:.|..:..|||...|.|.||||:||||||.|
Frog   542 KEAFQTAYMDLGGLGERVLGFCHLYLNEKEYPRGFSFDTEEMNFPTSGLCFAGLISMIDPPRATV 606

  Fly   588 PDAVAKCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATAIV 650
            ||||.|||:||:|||||||||||||||||.|||||:  :.|.||||.:..:.|..::.|.|.|.|
Frog   607 PDAVMKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRIPVEQVNKRDARACV 671

  Fly   651 VHGGELREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRAD 715
            ::||:|::|.:|||...:..|.|:|||||||||||||||:||:.|.||||||||||||||||:||
Frog   672 INGGQLKDMTSEELVEALKLHPEMVFARTSPQQKLIIVESCQKLGAIVAVTGDGVNDSPALKKAD 736

  Fly   716 IGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFV 780
            |||||||:|||.:|.|||||||||||||||.|:|:||:||||||||||||||.|:||:.|:|.::
Frog   737 IGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELAPYLIYI 801

  Fly   781 IFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGV 845
            ...:||.||.|.||.|::.||:.|::|||||:||||||...||:|..|||||:.|.:.:|.|:|:
Frog   802 TASVPLPLGCITILFIELCTDIFPSVSLAYERAESDIMHLKPRNPRRDRLVNEALAVYSYFQVGI 866

  Fly   846 IQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFV 910
            ||:.|.|..:|.:||:.|:.|:.:.|:|..|::::::||||.|||:||:.:|...:|...|.||:
Frog   867 IQSFAGFVDYFTVMAQEGWFPAYVLGLRSHWENQHLQDLEDSYGQQWTFSQRLYQQYNCYTVFFI 931

  Fly   911 SIVVTQVFDLLICKTRRNSILQQG-MGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWW 974
            ||.|.|:.|:||.||||.|:.||| ..|.||..|:|.:..:...|||.|..........|:|.||
Frog   932 SIEVCQIADVLIRKTRRLSVFQQGFFRNKVLVIAIVFQLCLGNFLCYCPGMPNVFNFMPIRFQWW 996

  Fly   975 IYAFPFGLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            :...|||:|||.:||.|:..:|||||.|.::|.||
Frog   997 LVPVPFGILIFVYDEIRKLGVRRNPGSWYDKELYY 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	533/995 (54%)
		Cation_ATPase_N	29..102	CDD:214842	21/72 (29%)
		E1-E2_ATPase	123..354	CDD:278548	138/230 (60%)
		Cation_ATPase	416..509	CDD:289987	49/93 (53%)
		COG4087	<673..738	CDD:226572	54/64 (84%)
		Cation_ATPase_C	785..994	CDD:279079	97/209 (46%)
atp4a	XP_031762229.1	ATPase-IIC_X-K	39..1031	CDD:273445	532/991 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930