DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JYalpha and atp1a2

DIOPT Version :9

Sequence 1:	NP_001104092.2	Gene:	JYalpha / 5740846	FlyBaseID:	FBgn0267363	Length:	1009	Species:	Drosophila melanogaster
Sequence 2:	NP_001096439.1	Gene:	atp1a2 / 100125050	XenbaseID:	XB-GENE-6034696	Length:	1020	Species:	Xenopus tropicalis

Alignment Length:	1004	Identity:	631/1004 - (62%)
Similarity:	775/1004 - (77%)	Gaps:	8/1004 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NG----KEKKKDIQSFKKDVETDNHKIPVDELLERLKTDPNMGLSFVEAKLRLEINGPNILTPQP 73
            ||    |:|:|::...||:|..|:||:.::|:..:..||...||:...|...|..:|||.|||.|
Frog    18 NGGGKKKQKEKEMDELKKEVAMDDHKLSMEEIGRKYGTDLAKGLTNARAAEVLAQDGPNALTPPP 82

  Fly    74 PTPKWIVFLKTMFGGFAILLWAGSFLCFVGYLIQLQTQHEPPDDNLYLGIALTVLVIVTGLFTYF 138
            .||:|:.|.:.:||||:||||.|:.|||:.|.||:..:.||.:||||||:.|..:|||||.|:|:
Frog    83 TTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQIAMEDEPINDNLYLGVVLAAVVIVTGCFSYY 147

  Fly   139 QVHKSSSIMDSFKNLVPQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAHGLKVD 203
            |..|||.|||||||:|||.|.||||||...:.::.:|.||:||:|.||||||||||:.|||.|||
Frog   148 QEAKSSKIMDSFKNMVPQQALVIREGEKLQINAEMVVVGDLVEIKGGDRVPADIRIIIAHGCKVD 212

  Fly   204 NSSLTGESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIANLAAGLDD 268
            |||||||||||.||.||||||||||:|:.|||||.:|||.||:||.|||.|||||||.||:||:.
Frog   213 NSSLTGESEPQTRSPEFTHENPLETRNICFFSTNCVEGTGRGIVINTGDRTVMGRIATLASGLEV 277

  Fly   269 VQSPISREIQLFIRFITIFAIILGLSFFAISLTLGYEFIDAVVFLIGIIVANVPEGLLVTVTVCL 333
            .::||:.||:.||..||..|:.||:|||.:||.|||.:::||:|||||||||||||||.||||||
Frog   278 GRTPIAMEIEHFIHIITGVAVFLGVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCL 342

  Fly   334 TLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWYDQIIVESDTTESFRGS 398
            ||||||||.|||||||||||||||||||||||||||||||||||||:|:|..|.|:||||...|:
Frog   343 TLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGT 407

  Fly   399 HFKIEDKSFNALFMCAALCNSAEFKGGQDDIPVFKKDVNGNASEAALLKFTETIFAGIGAFRQKH 463
            .|.....::.||...|.|||.|.||.||:.:.|.|:|..|:|||:||||..|.....:...|.::
Frog   408 TFDKRSPTWTALSRIAGLCNRAVFKVGQEKVAVSKRDTAGDASESALLKCIELSCGSVRKLRDRN 472

  Fly   464 IKLTEIPFNSTEKYQVSVHE-FNSSDGYFIVEMKGAPERILDRCSTIIIQGLSVELTPTLKLEFE 527
            .|:.|||||||.|:|:|:|| .:|.:|:.:| |||||||||||||||::.|....|...:|..|:
Frog   473 PKVAEIPFNSTNKFQLSIHEREDSPEGHLLV-MKGAPERILDRCSTIMLHGAEQPLDEEMKDAFQ 536

  Fly   528 EAYLEMGGMGERVLGFADLLLPMSKYPISYEFSADPPNFPLENLRFLGLISLIDPPRAAVPDAVA 592
            .||.|:||:|||||||..|.:|..|:...::|..|.|||||.:|.|:||||:||||||||||||.
Frog   537 NAYFELGGLGERVLGFCHLYIPADKFQRGFKFDTDEPNFPLTDLCFIGLISMIDPPRAAVPDAVG 601

  Fly   593 KCRSAGVRVIMVTGDHPITAKAIARSVGIIT--TPTAEDIAKQRGVTVLDIDSRQATAIVVHGGE 655
            ||||||::||||||||||||||||:.||||:  ..|.||||.:..:.|..::.|:|.|.||||.:
Frog   602 KCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIADRLNIPVNQVNPREAKACVVHGSD 666

  Fly   656 LREMKAEELDAVIYYHNEIVFARTSPQQKLIIVEACQRRGEIVAVTGDGVNDSPALKRADIGVAM 720
            |::|.:|:||.::..|.|||||||||||||||||.|||:|.||||||||||||||||:|||||||
Frog   667 LKDMTSEQLDDLLKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAM 731

  Fly   721 GISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFLFFVIFDIP 785
            ||:||||||||||||||||||||||.|:||||:||||||||||||||||:|||.|||.|:|.:||
Frog   732 GIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIP 796

  Fly   786 LALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMPRDPFEDRLVNKKLILMAYLQIGVIQTVA 850
            |.|||:.|||||:||||:||||||||.||||||.|.||:|..|:|||::||.|||.|||:||.:.
Frog   797 LPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALG 861

  Fly   851 CFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVLEYTAGTGFFVSIVVT 915
            .|||:|.|:||:||.||||.|||.|||.::..|:||.|||||||.:|||:|:|..|.||.||||.
Frog   862 GFFTYFVILAENGFLPSRLLGIRLDWDDRSNNDVEDSYGQEWTYEQRKVVEFTCHTAFFASIVVV 926

  Fly   916 QVFDLLICKTRRNSILQQGMGNHVLNFALVLEFIIACLLCYVPVFEKTLRMYSIKFIWWIYAFPF 980
            |..||:||||||||:.||||.|.:|.|.|:.|..:|..|.|.|..:..||||.:|..||..|||:
Frog   927 QWADLIICKTRRNSVFQQGMKNKILIFGLLEETALAAFLSYCPGMDVALRMYPLKVTWWFCAFPY 991

  Fly   981 GLLIFFFDESRRFLIRRNPGGWVEQETYY 1009
            .||||.:||.|:.::||:||||||:|:||
Frog   992 SLLIFLYDEVRKLILRRDPGGWVEKESYY 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	626/994 (63%)
		Cation_ATPase_N	29..102	CDD:214842	32/72 (44%)
		E1-E2_ATPase	123..354	CDD:278548	161/230 (70%)
		Cation_ATPase	416..509	CDD:289987	50/93 (54%)
		COG4087	<673..738	CDD:226572	59/64 (92%)
		Cation_ATPase_C	785..994	CDD:279079	128/208 (62%)
atp1a2	NP_001096439.1	ATPase-IIC_X-K	30..1020	CDD:273445	624/990 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D388324at2759
OrthoFinder	1	1.000	-	-		FOG0000283
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43294
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X416
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110