DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shawl and KCNB2

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_004761.2	Gene:	KCNB2 / 9312	HGNCID:	6232	Length:	911	Species:	Homo sapiens

Alignment Length:	1037	Identity:	265/1037 - (25%)
Similarity:	390/1037 - (37%)	Gaps:	325/1037 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSR---------LTEALANYDPVLNEYFFDRHPGVFTQIL 61
            |:.:||.|:.:|....||.::|.|||.:         |.|...:|:...||||||||||.||.||
Human    36 RVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSIL 100

  Fly    62 NYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPT 126
            |:|||||||...::|...|.:||::||:|...:|.||.:.|...::..|     ::|..|.|...
Human   101 NFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMN-----EELRREAETMR 160

  Fly   127 EEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTH 191
            |.:       .|...|   .|....:.|:|.:.::|:||..|||:|.:|:.||.:|.|:..|.|.
Human   161 ERE-------GEEFDN---TCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTL 215

  Fly   192 PGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSG 256
            |                             |..:|.::.|
Human   216 P-----------------------------ELQETDEFGQ------------------------- 226

  Fly   257 NFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVE 321
                                          ||   :.:.|.|                     ||
Human   227 ------------------------------LN---DNRQLAH---------------------VE 237

  Fly   322 LVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGLLEA 378
            .||..||.:|.::|.:.|||.|:|.|.|:|:||..|.|.:|..:        :.:......:::.
Human   238 AVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQI 302

  Fly   379 FSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQF 443
            |.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |....:|
Human   303 FRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDATKF 365

  Fly   444 KSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQAR 508
            .|||...|||.:|||||||||:.|||..|..||.||.:||||.||||:|:||:|||.||.. |.|
Human   366 TSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-QKR 429

  Fly   509 SKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAGGPGLGGHAVGH 573
            .:...|||..|    .|.||.                        |.:|.:.
Human   430 QEKAIKRREAL----ERAKRN------------------------GSIVSMN------------- 453

  Fly   574 SAAGAPMFKDAF-------------GGAKIGTVNVNGVNVIGLHPAQRTTTTMAMA--------- 616
                   .||||             .|....|.:....|  .|.|::......|::
Human   454 -------LKDAFARSMELIDVAVEKAGESANTKDSADDN--HLSPSRWKWARKALSETSSNKSFE 509

  Fly   617 -----------------MNEADPTPMSALTYQVPMLQPTPTPAHSHGHAHGHAHGLGPAS----- 659
                             .:.:.|..:||...::...:.|.|..|||.:.........|::
Human   510 NKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEI 574

  Fly   660 --------------------AAMTSSASLTGSAASAAVATAAAAAPAGPSFISSDYLSVPA-VQS 703
                                ..|.|::|:....:.|...|....:|..|...|...:..|. :..
Human   575 EMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPG 639

  Fly   704 LQPRAATTGHDFMLPLQPKLLGPLERK---DQHPLQLTAHNLASDTHQLMYSGHAHSQHKVGGGA 765
            .:......|..|:...:.|  ||..|.   :..|:.:|.:..||.:...::|
Human   640 TEEHQRARGPPFLTLSREK--GPAARDGTLEYAPVDITVNLDASGSQCGLHS------------- 689

  Fly   766 AVLNVPPTLSMSHTQMP----PGIASMGQRTPNLSFRPAHGASSQV-ATVQQPIPHSHA------ 819
                  |..|.:.|..|    .|...:..|:..::|:...|::.|. .:..:|:|.:.|
Human   690 ------PLQSDNATDSPKSSLKGSNPLKSRSLKVNFKENRGSAPQTPPSTARPLPVTTADFSLTT 748

  Fly   820 -CHAST-------------NCNIKISVASAGLSVGCPDEFRTPKVTLLDDLSDDVNSSTD-DCGD 869
             .|.||             ....::|....|.|.|....|  ||..|....|.:..|.|: |.|
Human   749 PQHISTILLEETPSQGDRPLLGTEVSAPCQGPSKGLSPRF--PKQKLFPFSSRERRSFTEIDTG- 810

  Fly   870 CCLVDDSDTYEGTTINNGPSGQENGTEAIGLDDGLLD--NDGEDEEDGEGSGVGGDSGDSLG 929
                ||.|..|      .|..:|. .:.....:...|  :||.|....||| ||..|....|
Human   811 ----DDEDFLE------LPGAREE-KQVDSSPNCFADKPSDGRDPLREEGS-VGSSSPQDTG 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	44/100 (44%)
		BTB_2	7..97	CDD:280393	43/98 (44%)
		Ion_trans	307..506	CDD:278921	91/206 (44%)
		Ion_trans_2	<449..499	CDD:285168	32/49 (65%)
KCNB2	NP_004761.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		BTB	37..143	CDD:197585	46/105 (44%)
		BTB_2	37..136	CDD:280393	43/98 (44%)
		Ion_trans	230..428	CDD:278921	93/221 (42%)
		Ion_trans_2	341..422	CDD:285168	48/82 (59%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	381..386		4/4 (100%)
		Kv2channel	471..759	CDD:281514	50/310 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..534		1/30 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..571		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..665		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..739		11/72 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	760..865		30/116 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..911
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810