DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and KCNQ4

DIOPT Version :9

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_004691.2 Gene:KCNQ4 / 9132 HGNCID:6298 Length:695 Species:Homo sapiens


Alignment Length:346 Identity:91/346 - (26%)
Similarity:137/346 - (39%) Gaps:81/346 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 GAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSI-GPTFRVTNYTSYSSGNFTASGQATPIATIKG 272
            |.||.|.....:|.|           .||...: ||          .||:.:|.||.:..|    
Human    37 GGGGSPRRLGLLGSP-----------LPPGAPLPGP----------GSGSGSACGQRSSAA---- 76

  Fly   273 GQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYG-------------------QPH---- 314
            .:|.|..:|...::|             .|..||...|.                   |.|    
Human    77 HKRYRRLQNWVYNVL-------------ERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELA 128

  Fly   315 -EAFFYVELVCNVWFFIEVIIRLIVSPNL------WQ----FIKSPVNIID---FTATLSFYTDV 365
             |....:|.|..|.|.:|.|:| :.|...      ||    |.:.|..:||   |.|:::.....
Human   129 NECLLILEFVMIVVFGLEYIVR-VWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAG 192

  Fly   366 MQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAY 430
            .|.....|..|.:...::|:|:.::.|.....::|.....|.:|||....:...|.::|.:.|.|
Human   193 TQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVY 257

  Fly   431 YAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIV 495
            .|||   :.::.|.|....|||..:|:||:||||..|.|:.|..:.|..||.|:...|||..::.
Human   258 LAEK---DANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILG 319

  Fly   496 SNFSMFYSHTQARSKLPKKRR 516
            |.|::.... |.|.|..:|||
Human   320 SGFALKVQE-QHRQKHFEKRR 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB 7..99 CDD:197585
BTB_2 7..97 CDD:280393
Ion_trans 307..506 CDD:278921 62/235 (26%)
Ion_trans_2 <449..499 CDD:285168 21/49 (43%)
KCNQ4NP_004691.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
MIG-14_Wnt-bd <92..190 CDD:284153 23/98 (23%)
Ion_trans 126..330 CDD:278921 59/208 (28%)
Ion_trans_2 246..320 CDD:285168 29/76 (38%)
Selectivity filter. /evidence=ECO:0000250 283..288 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 400..480
KCNQ_channel 474..653 CDD:281513
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..515
A-domain (Tetramerization) 546..650
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..606
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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