DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and KCNQ4

DIOPT Version :10

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_004691.2 Gene:KCNQ4 / 9132 HGNCID:6298 Length:695 Species:Homo sapiens


Alignment Length:346 Identity:91/346 - (26%)
Similarity:137/346 - (39%) Gaps:81/346 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 GAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSI-GPTFRVTNYTSYSSGNFTASGQATPIATIKG 272
            |.||.|.....:|.|           .||...: ||          .||:.:|.||.:..|    
Human    37 GGGGSPRRLGLLGSP-----------LPPGAPLPGP----------GSGSGSACGQRSSAA---- 76

  Fly   273 GQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYG-------------------QPH---- 314
            .:|.|..:|...::|             .|..||...|.                   |.|    
Human    77 HKRYRRLQNWVYNVL-------------ERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELA 128

  Fly   315 -EAFFYVELVCNVWFFIEVIIRLIVSPNL------WQ----FIKSPVNIID---FTATLSFYTDV 365
             |....:|.|..|.|.:|.|:| :.|...      ||    |.:.|..:||   |.|:::.....
Human   129 NECLLILEFVMIVVFGLEYIVR-VWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAG 192

  Fly   366 MQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAY 430
            .|.....|..|.:...::|:|:.::.|.....::|.....|.:|||....:...|.::|.:.|.|
Human   193 TQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVY 257

  Fly   431 YAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIV 495
            .|||   :.::.|.|....|||..:|:||:||||..|.|:.|..:.|..||.|:...|||..::.
Human   258 LAEK---DANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILG 319

  Fly   496 SNFSMFYSHTQARSKLPKKRR 516
            |.|::.... |.|.|..:|||
Human   320 SGFALKVQE-QHRQKHFEKRR 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723
Ion_trans 307..506 CDD:459842 62/235 (26%)
KCNQ4NP_004691.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Ion_trans 98..330 CDD:459842 62/236 (26%)
Interaction with CALM. /evidence=ECO:0000269|PubMed:29429937 342..351
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 400..480
KCNQ_channel 464..647 CDD:460954
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..515
Interaction with CALM. /evidence=ECO:0000250|UniProtKB:P51787 535..549
C-terminal assembly domain (tetramerization). /evidence=ECO:0000269|PubMed:17329207 546..650
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..606
Blue background indicates that the domain is not in the aligned region.

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