DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shawl and Kcnq1

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_114462.2	Gene:	Kcnq1 / 84020	RGDID:	621503	Length:	669	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	94/408 - (23%)
Similarity:	154/408 - (37%)	Gaps:	107/408 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 FRVDLPSGAHDAHGPGAG---------GPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTN 249
            |.::|..|     ||..|         |.|....||..|.        |..|....:||..||:
  Rat    36 FSLELAEG-----GPTGGTVYAPIAPTGAPGLAPPMSPPV--------SPVPAPADLGPRPRVS- 86

  Fly   250 YTSYSSGNFTASGQATPIATIKGGQRQRLKR-NINGSILNEFIEEKILGHNGRRKHGW------- 306
                          ..|..:|...:|..|.| :|.|.:.| |:|         |..||
  Rat    87 --------------LDPRVSIYSTRRPLLARTHIQGRVYN-FLE---------RPTGWKCFVYHF 127

  Fly   307 -----------------IETYGQ-PHEAFFYVELVCNVWFFIEVIIRLIVS------PNLW---Q 344
                             ||.|.. .....|::|:|..|:|..|.::||..:      ..:|   :
  Rat   128 TVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLR 192

  Fly   345 FIKSPVNIIDFTATLSFYTDVMQRMGE-----YTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTF 404
            |.:.|::|||....::  :.|:..:|.     .|..:.....::|:|:..:.|.....|:|....
  Rat   193 FARKPISIIDLIVVVA--SMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVV 255

  Fly   405 KASAKELTLLVFFLVLGIVFFASLAYYAEK--LQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAP 467
            ....:||...::...||::|.:...|.|||  :.::...:|.|....|||.:||:||:||||..|
  Rat   256 FIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVP 320

  Fly   468 KTYPGMFVGALCALAGVLTIALPVPVIVSNFSM----------FYSHTQARSKLPKKRRRVLPVE 522
            :|:.|..:.:..::..:...|||..::.|.|::          |.....|.:.|.:...|....|
  Rat   321 QTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAE 385

  Fly   523 QPRRK------REPTAPH 534
            .|...      |:|...|
  Rat   386 NPDSSTWKIYVRKPARSH 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585
		BTB_2	7..97	CDD:280393
		Ion_trans	307..506	CDD:278921	56/225 (25%)
		Ion_trans_2	<449..499	CDD:285168	18/49 (37%)
Kcnq1	NP_114462.2	Ion_trans	123..359	CDD:395416	55/237 (23%)
		Selectivity filter. /evidence=ECO:0000250	312..317		3/4 (75%)
		Interaction with CALM. /evidence=ECO:0000250\|UniProtKB:P51787	370..382		3/11 (27%)
		KCNQ_channel	<511..617	CDD:397540
		Interaction with CALM, calcium-dependent. /evidence=ECO:0000250\|UniProtKB:P51787	515..529
		Interaction with KCNE1 C-terminus. /evidence=ECO:0000250\|UniProtKB:P51787	535..572
		Interaction with AKAP9. /evidence=ECO:0000250\|UniProtKB:P51787	588..616
		C-terminal assembly domain. /evidence=ECO:0000250\|UniProtKB:P51787	589..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810