Protein Alignment Shawl and Kcnd2

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_113918.2
• Gene: Kcnd2 / 65180
• RGDID: 68393
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 741
• Identity: 202/741 - (27%)
• Similarity: 305/741 - (41%)
• Gaps: 184/741 - (24%)

  Fly     7 IILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRTGKLHY 71
            |:|||||.|::|::.||::.|.|.|.. :|....|.|...:|||||.|.:|..|||:||||||||
  Rat    43 IVLNVSGTRFQTWQDTLERYPDTLLGS-SERDFFYHPETQQYFFDRDPDIFRHILNFYRTGKLHY 106

  Fly    72 PTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLFGF 136
            |...|...::|||.|:||....:..||:..|. .|..:|...:.|..|.:|..
  Rat   107 PRHECISAYDEELAFFGLIPEIIGDCCYEEYK-DRRRENAERLQDDADTDNTG------------ 158

  Fly   137 EEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPSG 201
            |.||..      ...:.::|..|:.|.:||.|.:...::.|||.||||:..::|.|
  Rat   159 ESALPT------MTARQRVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVP--------- 208

  Fly   202 AHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQATP 266
                    .|..| ||
  Rat   209 --------CGSSP-GH------------------------------------------------- 215

  Fly   267 IATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWFFIE 331
            |..:..|:|..:                                     |||.::..|.:.|.:|
  Rat   216 IKELPCGERYAV-------------------------------------AFFCLDTACVMIFTVE 243

  Fly   332 VIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTD-VMQRMGEYTGLLEAFSIVRIMRLFKLTRHSP 395
            .::||..:|:.::|::|.::|||..|.|.:|.. ||....:.:|......:.|:.|:||.:|||.
  Rat   244 YLLRLAAAPSRYRFVRSVMSIIDVVAILPYYIGLVMTDNEDVSGAFVTLRVFRVFRIFKFSRHSQ 308

  Fly   396 GLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTV 460
            |||||.:|.|:.|.||..|:|.|.:.|:.||::.:||||  .:..::|.|||...|:.||||||:
  Rat   309 GLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GSSASKFTSIPAAFWYTIVTMTTL 371

  Fly   461 GYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQ-ARSKLPKKRRRVLPVEQP 524
            ||||:.|||..|...|::|:|:|||.|||||||||||||..|...| |..:..:|:.|:..:.
  Rat   372 GYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIR-- 434

  Fly   525 RRKREPTAPHRGRTNAIKQTPPTG------------PGLVAGGVVPVGAGGPGLGGH-------A 570
                   |...|..||..|:...|            |..|:..    |:.......|       .
  Rat   435 -------AAKSGSANAYMQSKRNGLLSNQLQSSEDEPAFVSKS----GSSFETQHHHLLHCLEKT 488

  Fly   571 VGHSAAGAPMFKDAFGGAKIGTVNVNGVNVIGLHPAQRTTTTMAMAMNEADPTPMSALTYQVPML 635
            ..|......:|:::.  .::.|||....:...|...|..|:|.....::.        |:::|
  Rat   489 TNHEFVDEQVFEESC--MEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKK--------TFRIP-- 541

  Fly   636 QPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASA-AVATAAAAAPAGPSFISSDYLSVP 699
                 .|:..|...|....|............|:.|.:|. |.............::::..:|:|
  Rat   542 -----NANVSGSHRGSVQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIP 601

  Fly   700 AVQSLQPRAATTGHDFMLPLQPKLLG 725
            .    .|.....|.|  .|..|:..|
  Rat   602 T----PPVTTPEGDD--RPESPEYSG 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	47/107 (44%)
		Ion_trans	307..506	CDD:459842	86/199 (43%)
Kcnd2	NP_113918.2	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000305|PubMed:14980206, ECO:0000305|PubMed:14980207	2..20
		BTB_POZ	6..144	CDD:453885	46/102 (45%)
		Interaction with KCNIP1. /evidence=ECO:0000305|PubMed:14980207	71..90		8/18 (44%)
		Ion_trans	184..415	CDD:459842	103/336 (31%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	308..321		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		3/4 (75%)
		DUF3399	470..546	CDD:463381	14/96 (15%)
		Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000305|PubMed:16820361	474..630		28/171 (16%)
		Required for dendritic targeting. /evidence=ECO:0000269|PubMed:12592409	474..489		1/14 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	600..623		7/28 (25%)
		PDZ-binding. /evidence=ECO:0000269|PubMed:11923279, ECO:0000269|PubMed:14559911	627..630