Protein Alignment Shawl and KCNK15

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_071753.2
• Gene: KCNK15 / 60598
• HGNCID: 13814
• Length: 330
• Species: Homo sapiens
• Alignment Length: 348
• Identity: 74/348 - (21%)
• Similarity: 116/348 - (33%)
• Gaps: 120/348 - (34%)

  Fly   275 RQRLKRNINGSILNEFIEEKILGHNGRRKHGW-IETY---------GQPHEAFFYVELVCNVWFF 329
            ||||.....|::              |||.|: .|.|         .:||.|....:...:.:|.
Human    37 RQRLLVQKRGAL--------------RRKFGFSAEDYRELERLALQAEPHRAGRQWKFPGSFYFA 87

  Fly   330 IEVIIRL---IVSPN---------LWQFIKSPVNIIDFTATLSFYTDVMQRMGEYTGLLEAFSIV 382
            |.||..:   ..:|.         .:..:..|:.::.|           |.:||...     ::|
Human    88 ITVITTIEYGHAAPGTDSGKVFCMFYALLGIPLTLVTF-----------QSLGERLN-----AVV 136

  Fly   383 RIMRLFKLTRHSPGLR-ILIHTFKASAKELTLLVFFLVLGIVFFASL-------AYYAEKLQDNP 439
            |  ||....:...||| ..:.|.......|......|.||.|.|:..       |||
Human   137 R--RLLLAAKCCLGLRWTCVSTENLVVAGLLACAATLALGAVAFSHFEGWTFFHAYY-------- 191

  Fly   440 DNQFKSIPLGLWWAIVTMTTVGYGD--------VAPKTYPGMFVGALCALAGVLTIALPVPVIVS 496
                        :..:|:||:|:||        ...:..|.:....|..|.|:..|...:.::|.
Human   192 ------------YCFITLTTIGFGDFVALQSGEALQRKLPYVAFSFLYILLGLTVIGAFLNLVVL 244

  Fly   497 NFSMFYSHTQARSKLPKKRRRVLPVEQPRRKRE------PTAPHRGRTNA--------------- 540
            .|.:      |.:..|::..|. |..:|....|      |..|.|...:|
Human   245 RFLV------ASADWPERAART-PSPRPPGAPESRGLWLPRRPARSVGSASVFCHVHKLERCARD 302

  Fly   541 -IKQTPPTGPGLVAGGVVP-VGA 561
             :..:||:.||:|.||..| :||
Human   303 NLGFSPPSSPGVVRGGQAPRLGA 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723
		Ion_trans	307..506	CDD:459842	45/235 (19%)
KCNK15	NP_071753.2	Ion_trans_2	<73..132	CDD:462301	11/69 (16%)
		Ion_trans_2	177..243	CDD:462301	15/85 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..276		4/20 (20%)