DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shawl and Kcnv1

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_067729.1	Gene:	Kcnv1 / 60326	RGDID:	621264	Length:	503	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	138/541 - (25%)
Similarity:	217/541 - (40%)	Gaps:	165/541 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IILNVSGIRYETYKATLKKIPATRLSRLTEALANY-------------------DPVLNEYFFDR 52
            :.:||.|.|:...:..|...|.|||.:|...:|:|                   :||.|||||||
  Rat    44 LTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRLGALAAAPSPLELCDDANPVDNEYFFDR 108

  Fly    53 HPGVFTQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDK 117
            ....|..:|:|||||:||....:|...|.:|:::||:|...::.||...|...::...||..  |
  Rat   109 SSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDF--K 171

  Fly   118 LDIENEKPTEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVS 182
            .|.::::...|.       |:..|.|.  | ..::.|:|.:.::|.|||.|:|...:|:.|:.||
  Rat   172 KDTDDQESQHES-------EQDFSQGP--C-PTVRQKLWDILEKPGSSTAARIFGVISIIFVAVS 226

  Fly   183 VISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRV 247
            :::..|.:
  Rat   227 IVNMALMS--------------------------------------------------------- 234

  Fly   248 TNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQ 312
                                                                  .:..|:..
  Rat   235 ------------------------------------------------------AELSWLNL--- 242

  Fly   313 PHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY-------------TD 364
              :....:|.||..||..|.|:|.:...:...|::...||||..|.|.||             |.
  Rat   243 --QLLEILEYVCISWFTGEFILRFLCVKDRCHFLRKVPNIIDLLAILPFYITLLVESLSGSHTTQ 305

  Fly   365 VMQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLA 429
            .::.:|.   |::...::|.:|:.||.|||.|||.|..|.....:|:.||:.||.:||..|:::.
  Rat   306 ELENVGR---LVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTIE 367

  Fly   430 YYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVI 494
            |:||  |..||..|.|:|...|||..:||||||||:.|.|..|..|..:|.|:|:|.:|||:.:|
  Rat   368 YFAE--QSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAII 430

  Fly   495 VSNFSMFYSHTQARSKLPKKR 515
            ...||..|...:.:....::|
  Rat   431 NDRFSACYFTLKLKEAAVRQR 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	37/110 (34%)
		BTB_2	7..97	CDD:280393	36/108 (33%)
		Ion_trans	307..506	CDD:278921	75/211 (36%)
		Ion_trans_2	<449..499	CDD:285168	23/49 (47%)
Kcnv1	NP_067729.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		BTB_POZ	44..163	CDD:365784	39/118 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..192		6/29 (21%)
		Ion_trans	212..438	CDD:395416	82/346 (24%)
		Selectivity filter. /evidence=ECO:0000250	395..400		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910