DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shawl and kcnq5b

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	XP_697081.4	Gene:	kcnq5b / 568646	ZFINID:	ZDB-GENE-090312-178	Length:	974	Species:	Danio rerio

Alignment Length:	375	Identity:	95/375 - (25%)
Similarity:	149/375 - (39%)	Gaps:	88/375 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 HDAHGPGAG-----GPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSY-SSGNFTAS 261
            |.....|:|     .|.|         ....|..|::...:       |:.|..|. ..|..:||
Zfish     5 HSGDEAGSGLWMNTSPGH---------HAESYGLHNVECDN-------RMKNNCSRPGDGLLSAS 53

  Fly   262 GQATPIATIKGGQRQRLKRNINGSILNEFIEEKILG-HNGRR--KHGWIETY-----GQPHE-AF 317
            ...|..:   |.:|.|.|:....|:|.:.:   :.| .:|||  ::..|:.|     .:|.. ||
Zfish    54 HAGTGAS---GTERDRGKQGARLSLLGKPL---VYGTQSGRRNARYRRIQNYLYNVLERPRSWAF 112

  Fly   318 FY---------------------------------VELVCNVWFFIEVIIRLIVSPNL------W 343
            .|                                 :|.|..|.|.:|.||| |.|...      |
Zfish   113 IYHAFVFVLVFGCLVLSVFSTIPDHQEMASQSLLILEFVMIVVFGLEYIIR-IWSAGCCCRYRGW 176

  Fly   344 Q----FIKSP---VNIIDFTATLSFYTDVMQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILI 401
            |    |.:.|   ::||...|:::..:...|.....|..|.:...::|:|:.::.|.....::|.
Zfish   177 QGRLRFARKPFCVIDIIVLIASVAVVSAGSQSNIFATSALRSLRFLQILRMVRMDRRGGTWKLLG 241

  Fly   402 HTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVA 466
            ....|.:|||....:...|.::|.:.|.|..|| :.|.|  |.:....|||..:|:||:||||..
Zfish   242 SVVYAHSKELVTAWYIGFLVLIFSSFLVYLVEK-EFNKD--FATYADALWWGTITLTTIGYGDKT 303

  Fly   467 PKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRR 516
            |||:.|..:.|..||.|:....||..::.|.|::.... |.|.|..:|||
Zfish   304 PKTWTGRMLSAGFALLGISFFTLPAGILGSGFALKVQE-QHRQKHFEKRR 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585
		BTB_2	7..97	CDD:280393
		Ion_trans	307..506	CDD:278921	65/250 (26%)
		Ion_trans_2	<449..499	CDD:285168	21/49 (43%)
kcnq5b	XP_697081.4	Ion_trans	145..343	CDD:278921	59/202 (29%)
		Ion_trans_2	259..333	CDD:285168	29/76 (38%)
		KCNQ_channel	443..625	CDD:281513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810