Protein Alignment Shawl and kcnb2b

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: XP_695259.4
• Gene: kcnb2b / 566883
• ZFINID: ZDB-GENE-091113-38
• Length: 831
• Species: Danio rerio
• Alignment Length: 1010
• Identity: 248/1010 - (24%)
• Similarity: 373/1010 - (36%)
• Gaps: 388/1010 - (38%)

  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVL----------NEYFFDRHPGVFTQI 60
            |:.:||.|:.:|....||.::|.|||.:|.:. ..:|.::          ||||||||||.||.|
Zfish    36 RVRINVGGLNHEVLWRTLDRLPRTRLGKLRDC-NTHDSLMEVCDDYCLNENEYFFDRHPGAFTSI 99

  Fly    61 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKP 125
            ||:|||||||...::|...|.:||::||:|...:|.||.:.|...::..|.       ::..|..
Zfish   100 LNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNE-------ELRREAE 157

  Fly   126 TEEQIARLFGFEEALSNGELN--CWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCL 188
            |         ..|....||.:  |....:.|:|.:.::||||..|||:|.:|:.||.:|.::..|
Zfish   158 T---------LREREGEGEFDNTCCPEKRKKLWELLEKPSSSVAAKILAIISILFIVLSTVALSL 213

  Fly   189 KTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSY 253
            .|.|..:|                             |.::.|.:..|.
Zfish   214 NTLPELQV-----------------------------TDEFGQANDNPQ---------------- 233

  Fly   254 SSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFF 318
                                                      |.|
Zfish   234 ------------------------------------------LAH-------------------- 236

  Fly   319 YVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGL 375
             ||.||..||.:|.::|.:.|||.|:|.|.|:|:||..|.|.:|..:        :.:......:
Zfish   237 -VEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRV 300

  Fly   376 LEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPD 440
            ::.|.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |...
Zfish   301 VQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDA 363

  Fly   441 NQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHT 505
            .:|.|||...|||.:|||||||||:.|:|..|..||.||.:||||.||||:|:||:|||.||..
Zfish   364 TKFTSIPASFWWATITMTTVGYGDIYPQTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE- 427

  Fly   506 QARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAGGPGLGGHA 570
            |.|.:...|||..|    .|.||.                        |.:|.:.
Zfish   428 QKRQEKAIKRREAL----ERAKRN------------------------GSIVSMN---------- 454

  Fly   571 VGHSAAGAPMFKDAFGGAKIGTVNVNGVNVIGLHPAQRTTTTMAMAMNEADPTPMSALTYQVPML 635
                      .||||.                     |:...|.:.:.::|...:
Zfish   455 ----------LKDAFA---------------------RSMELMDVTVEKSDDKRL---------- 478

  Fly   636 QPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASAAVATAAAAAPAGPSFISSDYLSVPA 700
                    :..|......|:...:::.||..|.....               |:..|.:|:.:|:
Zfish   479 --------TDNHLSPSRWGIPQRTSSDTSLRSFDKKF---------------PNSGSQEYVHMPS 520

  Fly   701 VQSLQPRAATTGHDFMLPLQPKLLGPLERKDQHPLQLTAHNLASDTHQLMYSGHAHSQHKVGGGA 765
                                             |..|.|.||     :.||:
Zfish   521 ---------------------------------PQHLNAQNL-----EEMYN------------- 534

  Fly   766 AVLNVPPTLSMSHTQMPPGIASMGQRTPNLSFRPAHGASSQV---------ATVQQPIPHSHACH 821
                     .|:.||      |....:.:.|.:||..:..:|         |..|||       .
Zfish   535 ---------QMTKTQ------SFSDLSTSNSTQPAVVSKHEVELEMKEVPTAVKQQP-------K 577

  Fly   822 ASTNCNIKISVASAGLSVGCPDEF------------------RTPKVT--------LLDDLSDD- 859
            ..|..::: |::|......|..||                  |.|||:        ...|||.:
Zfish   578 ERTITDVR-SISSVDSFASCTAEFGQGEKATTPSHTAEQFQQRLPKVSPQLHLGQLTPSDLSPEE 641

  Fly   860 ----VNSSTDDCGDCCLVDD-SDTYEGT--------------TINNGPSGQENGTEAIGLDDGLL 905
                ||..|||..:  .|:: ..:..||              |..:.|....|.:....:::.||
Zfish   642 NSGIVNRDTDDLNE--FVENIRSSIRGTNPIKAKGLKVNFIETPEDAPLTPPNTSSPQDINNSLL 704

  Fly   906 DNDGEDEEDGEGSGVGGDS----GDSLGGIYIGPR 936
            :   :|..:||.|.:..||    |:|:.|:.:.|:
Zfish   705 E---DDSPEGECSPLCSDSETVGGNSMEGLVLSPK 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	47/118 (40%)
		Ion_trans	307..506	CDD:459842	90/206 (44%)
kcnb2b	XP_695259.4	BTB_POZ_KCNB2	19..145	CDD:349719	46/109 (42%)
		Ion_trans	193..429	CDD:459842	107/346 (31%)
		Kv2channel	480..706	CDD:397541	54/319 (17%)