DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and Kcnd3

DIOPT Version :10

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_064315.1 Gene:Kcnd3 / 56543 MGIID:1928743 Length:655 Species:Mus musculus


Alignment Length:540 Identity:162/540 - (30%)
Similarity:248/540 - (45%) Gaps:132/540 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRTGKLHY 71
            |:|||||.|::|::.||::.|.|.|.. ||....::....||||||.|.||..:||:||||||||
Mouse    42 IVLNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHY 105

  Fly    72 PTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLFGF 136
            |...|...:::||.|:|:....:..||:..|. .|..:|...::|..|.||.:.:...::     
Mouse   106 PRYECISAYDDELAFYGILPEIIGDCCYEEYK-DRKRENAERLMDDNDSENNQESMPSLS----- 164

  Fly   137 EEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPSG 201
                          .:..:|..|:.|.:||.|.:...::.|||.||||:..::|.|         
Mouse   165 --------------FRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVP--------- 206

  Fly   202 AHDAHGPGAGGPPHGHD-PMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQAT 265
                    .|..|...: |.||        ::|:                               
Mouse   207 --------CGTVPGSKELPCGE--------RYSV------------------------------- 224

  Fly   266 PIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWFFI 330
                                                              |||.::..|.:.|.:
Mouse   225 --------------------------------------------------AFFCLDTACVMIFTV 239

  Fly   331 EVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTD-VMQRMGEYTGLLEAFSIVRIMRLFKLTRHS 394
            |.::||..:|:.::||:|.::|||..|.:.:|.. ||....:.:|......:.|:.|:||.:|||
Mouse   240 EYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHS 304

  Fly   395 PGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTT 459
            .|||||.:|.|:.|.||..|:|.|.:.|:.||::.:||||  .:..::|.|||...|:.||||||
Mouse   305 QGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK--GSSASKFTSIPASFWYTIVTMTT 367

  Fly   460 VGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQ-ARSKLPKKRRRVLPVEQ 523
            :||||:.|||..|...|::|:|:|||.|||||||||||||..|...| |..:..:|:.|:..:..
Mouse   368 LGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRV 432

  Fly   524 PRRKREPTAPHRGRTNAIKQ 543
            .:........|..|...:.:
Mouse   433 AKTGSSNAYLHSKRNGLLNE 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723 45/107 (42%)
Ion_trans 307..506 CDD:459842 86/199 (43%)
Kcnd3NP_064315.1 BTB_POZ_KCND3 6..143 CDD:349726 44/102 (43%)
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000250|UniProtKB:Q9UK17 6..21
Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q9UK17 70..78 1/7 (14%)
Ion_trans 186..412 CDD:459842 101/333 (30%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 367..372 3/4 (75%)
DUF3399 468..563 CDD:463381
Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000250|UniProtKB:Q9UK17 470..487
Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 472..487
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 523..565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..655
Blue background indicates that the domain is not in the aligned region.

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