Protein Alignment Shawl and KCNQ5

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_001153605.1
• Gene: KCNQ5 / 56479
• HGNCID: 6299
• Length: 951
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 72/282 - (25%)
• Similarity: 116/282 - (41%)
• Gaps: 55/282 - (19%)

  Fly   276 QRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFY--------------------- 319
            |..:||:....:..::...:     .|..||...|    .||.:
Human   100 QSCRRNVKYRRVQNYLYNVL-----ERPRGWAFIY----HAFVFLLVFGCLILSVFSTIPEHTKL 155

  Fly   320 -------VELVCNVWFFIEVIIRLIVSPNL------WQ----FIKSPVNIID---FTATLSFYTD 364
                   :|.|..|.|.:|.||| |.|...      ||    |.:.|..:||   ..|:::..:.
Human   156 ASSCLLILEFVMIVVFGLEFIIR-IWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSA 219

  Fly   365 VMQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLA 429
            ..|.....|..|.:...::|:|:.::.|.....::|.....|.:|||....:...|.::|.:.|.
Human   220 KTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLV 284

  Fly   430 YYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVI 494
            |..||   :.:.:|.:....|||..:|:||:||||..|.|:.|..:.|..||.|:...|||..::
Human   285 YLVEK---DANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGIL 346

  Fly   495 VSNFSMFYSHTQARSKLPKKRR 516
            .|.|::.... |.|.|..:|||
Human   347 GSGFALKVQE-QHRQKHFEKRR 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723
		Ion_trans	307..506	CDD:459842	60/239 (25%)
KCNQ5	NP_001153605.1	Ion_trans	126..358	CDD:459842	60/240 (25%)
		Interaction with CALM. /evidence=ECO:0000269|PubMed:29429937	370..378
		KCNQ_channel	466..653	CDD:460954
		Interaction with CALM. /evidence=ECO:0000269|PubMed:29429937	540..547
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	674..697
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	895..938