Protein Alignment Shawl and kcnq5a

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: XP_073777019.1
• Gene: kcnq5a / 556841
• ZFINID: ZDB-GENE-090312-185
• Length: 1028
• Species: Danio rerio
• Alignment Length: 883
• Identity: 165/883 - (18%)
• Similarity: 277/883 - (31%)
• Gaps: 290/883 - (32%)

  Fly   266 PIA-TIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFY---------- 319
            |:| :.:.|:|....|.:...:.|..          .|...|...|    .||.:
Zfish    73 PLAYSAQSGRRNARYRKLQNYLYNVL----------ERPRAWAFVY----HAFVFTLVFGCLVLS 123

  Fly   320 ------------------VELVCNVWFFIEVIIRLIVSPNL------WQ----FIKSP---VNII 353
                              :|.|..|.|.:|.||| |.|...      ||    |.:.|   ::||
Zfish   124 VFSTIPAHMDLSNHCLLILEFVMIVVFGLEYIIR-IWSAGCCCRYRGWQGRLRFARKPFCVIDII 187

  Fly   354 DFTATLSFYTDVMQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFL 418
            ...|:::..:...|.....|..|.:...::|:|:.::.|.....::|.....|.:|||....:..
Zfish   188 VLIASIAVVSAGSQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELVTAWYIG 252

  Fly   419 VLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAG 483
            .|.::|.:.|.|..||   ..:.||.:....|||..:|:||:||||..|:|:.|..:.|..||.|
Zfish   253 FLVLIFSSFLVYLVEK---EFNKQFATYADALWWGTITLTTIGYGDKTPQTWTGRLLSAGFALLG 314

  Fly   484 VLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRR------------------------------- 517
            :...|||..::.|.|::.... |.|.|..:|||.
Zfish   315 ISFFALPAGILGSGFALKVQE-QHRQKHFEKRRNPAASLIQAAWRLYSTDLSRSYLSATWLFYKS 378

  Fly   518 VLPVEQPRRKRE-PTAPHRGRTN---------------------AIKQTPPTGPGLVAGGVVPVG 560
            |||   |:||.: .:...:|.:|                     .::...|.|..:.:..:....
Zfish   379 VLP---PQRKDQGESISSKGHSNRQRLFRRYTTRKYSQKLSFRERVRMASPRGQSVKSRQMSVND 440

  Fly   561 AGGPGLGGHAVGHSAAGA-------------PMFK------------------DAFG-------- 586
            ...||......|.|.|..             |..:                  |||.
Zfish   441 RRSPGTEVAVEGSSPAKVQKSWSFNDRTRFRPSLRLKSQSRTTTEADTTLGPDDAFDDKACHCDV 505

  Fly   587 -----GAKIGTVNVNGVNVIGLHPAQRTTTTMAMAMNEAD------------------------- 621
                 .|.:..| :..:.::..|.|::.........:..|
Zfish   506 TVEDLSAPLKAV-IRAIRIMKFHVAKKKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRLDT 569

  Fly   622 ---PTPMS--ALTYQVPMLQPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASAAVATAA 681
               |..:|  |.|:..|.|....:.|.....|.|....:||.....|.:.:|:..:.....:.:.
Zfish   570 IVGPQTLSSKAKTFSSPSLHLYYSQAKRKHSAPGLNSAMGPHQTLSTKARNLSSPSLHLYYSQSK 634

  Fly   682 AAAPAGPSFISSDYLSV--PAVQSLQPRAATTGHDFML------------PLQPKL--------- 723
            .........:....:||  ...:.:.|...:..||..:            .::.||
Zfish   635 KKHAGVDQILGKGQISVDRKGREKILPEGESLEHDMSMLGRVCKVERQVQSIESKLDSLLDIYRQ 699

  Fly   724 ---------LG----PLERKDQ------------HPLQLT----AHNLASDTHQLMY-------- 751
                     ||    ||...||            ...|||    :.:.:|:.|:.::
Zfish   700 VLQKGSSSMLGLSALPLFELDQTSDYQSSLHSKESSSQLTGSGVSRSCSSNLHRGLHLALAPSEL 764

  Fly   752 ---SGHAHSQHKVGGGAAVLNVPPTLSMSHTQMPPGIASMGQRTPNLSFRPAHGASSQVATVQQP 813
               :|:.||.........:.|.|.:....:...||.|.     ||| :...:|...|::.   :|
Zfish   765 NLGTGYPHSASSFSPSPLLNNQPSSPDSFYPSSPPPIL-----TPN-NLSRSHQRFSELT---RP 820

  Fly   814 IPHSHACHASTNCNIKISVASAGLSVGCPDEFRTPKVTLLDDLSDDVNSSTDDCGDCCLVDDSDT 878
            :|..|    ||:..:::           |.....|.......:.:.:..|..:|...||:.
Zfish   821 VPTVH----STSTTLQL-----------PPMVPAPPGRPTSLIPETLQESRAECPTNCLLG---- 866

  Fly   879 YEGTTINNGPSGQENGTEAIGLDDGLLDN-DGEDEEDG 915
                |.|...|.:|  .|:|.....|.|. :...:|||
Zfish   867 ----TQNEVESDKE--AESIPSTVQLRDKPERNSKEDG 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723
		Ion_trans	307..506	CDD:459842	61/239 (26%)
kcnq5a	XP_073777019.1	None