DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shawl and Shal

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_001097646.1	Gene:	Shal / 40129	FlyBaseID:	FBgn0005564	Length:	571	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	168/520 - (32%)
Similarity:	244/520 - (46%)	Gaps:	139/520 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRTGK 68
            :.::::||||.|:||::.||:|.|.|.|.. .|....||....||||||.|.:|..|||||||||
  Fly    40 DEKLLINVSGRRFETWRNTLEKYPDTLLGS-NEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGK 103

  Fly    69 LHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARL 133
            ||||...|...::|||.|:|:..:.:..||:..|. .|..:|...::|      :|.:|
  Fly   104 LHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYR-DRKRENAERLMD------DKLSE------ 155

  Fly   134 FGFEEALSNGELNCWQ--RIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRV 196
                    ||:.|..|  .::.|:|..|:.|.:||.|.:...::.|||.|||::..::|
  Fly   156 --------NGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVET------ 206

  Fly   197 DLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTAS 261
             :|.|    |.||..|
  Fly   207 -VPCG----HRPGRAG------------------------------------------------- 217

  Fly   262 GQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNV 326
                   |:..|:|.::                                     .||.::..|.:
  Fly   218 -------TLPCGERYKI-------------------------------------VFFCLDTACVM 238

  Fly   327 WFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY-----TDVMQRMGEYTGLLEAFSIVRIMR 386
            .|..|.::||..:|:..:|::|.::|||..|.:.:|     ||    ..:.:|......:.|:.|
  Fly   239 IFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITD----NDDVSGAFVTLRVFRVFR 299

  Fly   387 LFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLW 451
            :||.:|||.|||||.:|.|:.|.||..|||.|.:.|:.||::.:|||| ..|..| |.|||...|
  Fly   300 IFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEK-NVNGTN-FTSIPAAFW 362

  Fly   452 WAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRR 516
            :.||||||:||||:.|:|..|..||.:|:|:|||.|||||||||||||..|...|...|...:|:
  Fly   363 YTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRK 427

Fly 517 516
Fly 428 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	44/91 (48%)
		BTB_2	7..97	CDD:280393	43/89 (48%)
		Ion_trans	307..506	CDD:278921	87/203 (43%)
		Ion_trans_2	<449..499	CDD:285168	32/49 (65%)
Shal	NP_001097646.1	BTB_POZ_Shal-like	6..144	CDD:349727	47/105 (45%)
		Ion_trans	188..415	CDD:395416	103/336 (31%)
		DUF3399	445..540	CDD:403174
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439071
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
	5	4.840