Protein Alignment Shawl and Kcnf1

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_963289.3
• Gene: Kcnf1 / 382571
• MGIID: 2687399
• Length: 493
• Species: Mus musculus
• Alignment Length: 608
• Identity: 170/608 - (27%)
• Similarity: 248/608 - (40%)
• Gaps: 173/608 - (28%)

  Fly     3 GEN-RIILNVSGIRYETYKATLKKIPATRLSRLTEALA-----------NYDPVLNEYFFDRHPG 55
            ||: .|::||.|:|...|...|.:.|.|||:.|...||           :|||...|::|||.|.
Mouse    20 GEDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPD 84

  Fly    56 VFTQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLA-----IL 115
            .|..::..|..|::|....:|...|:.|::||.:|...::.||.|..|..|:....:|     ||
Mouse    85 AFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLIL 149

  Fly   116 DKLDIENEKPTEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIF 180
            |.|.::                  .:.|.   |:|.:..:|...::|.||..|::||.:|...|.
Mouse   150 DDLGVD------------------AAEGR---WRRCQKCVWKFLEKPESSCPARVVAVLSFLLIL 193

  Fly   181 VSVISFCLKTHPGFR-VDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPT 244
            ||.:..|:.|.|..: ||
Mouse   194 VSSVVMCMGTIPELQVVD----------------------------------------------- 211

  Fly   245 FRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIET 309
                     |.||                                           |.:|..:|.
Mouse   212 ---------SEGN-------------------------------------------RVEHPTLEN 224

  Fly   310 YGQPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY-----TDVMQRM 369
                      ||..|..||.:|.::||..|||...|..|.:||:|..|.|.||     |.:..||
Mouse   225 ----------VETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARM 279

  Fly   370 GEYTGL---LEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYY 431
            .|.|.:   ::|..|:||.|:|||.|||.||:.|.:..|.|.|||.||:.:|.:||..|::|.|.
Mouse   280 MELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYT 344

  Fly   432 AEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVS 496
            .|  |.:|:..|||||...||||:|||||||||:.|||..|....|:..|.||:.||||:..|::
Mouse   345 ME--QSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIIN 407

  Fly   497 NFSMFYSHTQARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGA 561
            ||..:|:..:......|....::.:.....:.:|    .|..:.:...||.          |...
Mouse   408 NFVRYYNKQRVLETAAKHELELMELNSSSAEGKP----GGSRSDLDTLPPE----------PAAR 458

  Fly   562 GGPGLGGH-AVGHSAAGAPMFKD 583
            .||..|.. .:.||....|:..:
Mouse   459 EGPSWGSRLKLSHSDTFIPLLTE 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	39/127 (31%)
		Ion_trans	307..506	CDD:459842	90/206 (44%)
Kcnf1	NP_963289.3	BTB_POZ_Kv5_KCNF1	23..138	CDD:349690	37/114 (32%)
		Ion_trans	181..417	CDD:459842	107/346 (31%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..468		8/47 (17%)