Protein Alignment Shawl and KCNS3

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_001269357.1
• Gene: KCNS3 / 3790
• HGNCID: 6302
• Length: 491
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 141/539 - (26%)
• Similarity: 227/539 - (42%)
• Gaps: 149/539 - (27%)

  Fly     4 ENRIILNVSGIRYETYKATLKKIPATRLSRL---------TEALANYDPVLNEYFFDRHPGVFTQ 59
            |..:.|||.|.:....::||.:.|.|||.:|         .|...:|.....||:|||:|.:|..
Human    14 EELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRY 78

  Fly    60 ILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKL--DIEN 122
            :||:|.|||||...::|...|.:|:|:||::...::.||.:.|. .|..:|.....|:.  |:..
Human    79 VLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQ-ERKEENHEKDWDQKSHDVST 142

  Fly   123 EKPTEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFC 187
            :...||...    ||:.|...:...:.:::.|||...:.|:....||::|..|:..:..|:::.|
Human   143 DSSFEESSL----FEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMC 203

  Fly   188 LKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTS 252
            :
Human   204 V---------------------------------------------------------------- 204

  Fly   253 YSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAF 317
            :|...|                     :|.:|.:.:..:|.
Human   205 HSMSEF---------------------QNEDGEVDDPVLEG------------------------ 224

  Fly   318 FYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY-----------TDVMQRMGE 371
              ||:.|..||..|:.:||..:|...:|.|:|:|||||.:.:.||           ::.::.||:
Human   225 --VEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGK 287

  Fly   372 YTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQ 436
            ...:|.   ::||.|:.||.|||.|||.|..|.:.|..|:.||:.||.:||..|:.|.|..||
Human   288 VVQILR---LMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEK-- 347

  Fly   437 DNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMF 501
            |:..:...|||:..|||.::||||||||..|.|..|..:.:.|.:.|:|.:|||:.:|.:.||.:
Human   348 DDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKY 412

  Fly   502 YSH------TQARSKLPKK 514
            |..      .|.....|:|
Human   413 YQKQKDIDVDQCSEDAPEK 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	35/100 (35%)
		BTB_2	7..97	CDD:280393	34/98 (35%)
		Ion_trans	307..506	CDD:278921	76/215 (35%)
		Ion_trans_2	<449..499	CDD:285168	21/49 (43%)
KCNS3	NP_001269357.1	BTB_2	17..116	CDD:280393	34/98 (35%)
		BTB	44..122	CDD:197585	26/77 (34%)
		Ion_trans	219..417	CDD:278921	77/228 (34%)
		Ion_trans_2	329..411	CDD:285168	35/83 (42%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820