Protein Alignment Shawl and KCNS2

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Alignment Length: 529
• Identity: 153/529 - (28%)
• Similarity: 231/529 - (43%)
• Gaps: 155/529 - (29%)

  Fly     2 DGENRIILNVSGIRYETYKATLKKIPATRLSRL---------TEALANYDPVLNEYFFDRHPGVF 57
            |||.||  ||.|.:......||.:.|.|||.||         .|...:||.|..|::|||:|.:|
Human    16 DGEIRI--NVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELF 78

  Fly    58 TQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIEN 122
            ..:|::|.|||||...::|...|.:|:|:||::...::.||  :||.|.         .|::.|.
Human    79 PYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCC--SYSYHG---------RKVEPEQ 132

  Fly   123 EKPTE--EQIARLFGFEEALS--------NGE-LNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSV 176
            ||..|  :|.:....|:|.|:        :|: |..::|   ::|...|.|..|..:::.:.:|:
Human   133 EKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRR---QLWLALDNPGYSVLSRVFSILSI 194

  Fly   177 FFIFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSI 241
            ..:..|:|:.||.:.|.|::           |.:.|.| |.||..|
Human   195 LVVMGSIITMCLNSLPDFQI-----------PDSQGNP-GEDPRFE------------------- 228

  Fly   242 GPTFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGW 306
                                                                 |:.|.|
Human   229 -----------------------------------------------------IVEHFG------ 234

  Fly   307 IETYGQPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY-TDVMQRMG 370
                              ..||..|::.|..|:|:..:|.|:.:|:||..:.:.|| |.|:..:.
Human   235 ------------------IAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVV 281

  Fly   371 EYTGLL-------EAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASL 428
            |.|..|       :...::||.|:.||.|||.|||.|..|.|.|.||:.||:.:|.:||..|:.:
Human   282 ESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVV 346

  Fly   429 AYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPV 493
            ||..|| ::|  ....:||...|||.|:|||||||||.|.|..|....:.|.|||:|.:.||:.:
Human   347 AYTIEK-EEN--EGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITL 408

  Fly   494 IVSNFSMFY 502
            |.:.||.||
Human   409 IFNKFSHFY 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	42/119 (35%)
		Ion_trans	307..506	CDD:459842	76/204 (37%)
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	41/109 (38%)
		Ion_trans	186..421	CDD:459842	93/343 (27%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)