Protein Alignment Shawl and KCNS1

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: XP_016883335.1
• Gene: KCNS1 / 3787
• HGNCID: 6300
• Length: 527
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 143/520 - (27%)
• Similarity: 221/520 - (42%)
• Gaps: 125/520 - (24%)

  Fly     9 LNVSGIRYETYKATLKKIPATRLSRLTEALA---------NYDPVLNEYFFDRHPGVFTQILNYY 64
            :||.|:|.:.....|.:.|.|||.||..|.:         :||....|::||||||.|..:|::|
Human    55 VNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFY 119

  Fly    65 RTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQ 129
            |||.||...::|...|.:|.::|||..|.:..||.:.|...|.||......|.....:..|..::
Human   120 RTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDE 184

  Fly   130 IARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGF 194
            |:.:  ..|....|...| .|::.::|...:.|..|..:|:.:.:|:..:..|:.:.|:.:.|.:
Human   185 ISDV--QRELARYGAARC-GRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEY 246

  Fly   195 RVDLPSGAHDAHGPGAGGPPHG--HDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGN 257
            :....:.|..|  ..||..|.|  .||:
Human   247 QAREAAAAVAA--VAAGRSPEGVRDDPV------------------------------------- 272

  Fly   258 FTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVEL 322
                                |:|                                       :|.
Human   273 --------------------LRR---------------------------------------LEY 278

  Fly   323 VCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVM----------QRMGEYTGLLE 377
            .|..||..||..||:::|:...|...|:|:||..:.|.||..::          :..|....:::
Human   279 FCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVVQ 343

  Fly   378 AFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQ 442
            .|.::||.|:.||.|||.|||.|..|.|.|.:|:.:|:.:|.:|:..|:.:||.|||   ..|..
Human   344 VFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEK---EEDVG 405

  Fly   443 FKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQA 507
            |.:||...||..|:|||||||||.|.|..|....:.|.|.|:|.:|||:.:|.:.||.||...:|
Human   406 FNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKA 470

  Fly   508  507
            Human   471  470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	37/98 (38%)
		BTB_2	7..97	CDD:280393	36/96 (38%)
		Ion_trans	307..506	CDD:278921	75/208 (36%)
		Ion_trans_2	<449..499	CDD:285168	23/49 (47%)
KCNS1	XP_016883335.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820