Protein Alignment Shawl and KCNQ1

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_000209.2
• Gene: KCNQ1 / 3784
• HGNCID: 6294
• Length: 676
• Species: Homo sapiens
• Alignment Length: 417
• Identity: 96/417 - (23%)
• Similarity: 164/417 - (39%)
• Gaps: 113/417 - (27%)

  Fly   150 RIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPSGAHDAHG------- 207
            |.:.|.|.....|.:..|:   ||::             |..| |.::|..|. .|.|
Human     9 RAERKRWGWGRLPGARRGS---AGLA-------------KKCP-FSLELAEGG-PAGGALYAPIA 55

  Fly   208 PGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQATPIATIKG 272
            |||.||.    |...|...      :..|.:..:||...|:               ..|..:|..
Human    56 PGAPGPA----PPASPAAP------AAPPVASDLGPRPPVS---------------LDPRVSIYS 95

  Fly   273 GQRQRLKR-NINGSILNEFIEEKILGHNGRRKHGW------------------------IETYGQ 312
            .:|..|.| ::.|.:.| |:|         |..||                        ||.|..
Human    96 TRRPVLARTHVQGRVYN-FLE---------RPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAA 150

  Fly   313 -PHEAFFYVELVCNVWFFIEVIIRLIVS------PNLW---QFIKSPVNIIDFTATLSFYTDVMQ 367
             .....|::|:|..|:|..|.::||..:      ..||   :|.:.|::|||....::  :.|:.
Human   151 LATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVA--SMVVL 213

  Fly   368 RMGE-----YTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFAS 427
            .:|.     .|..:.....::|:|:..:.|.....|:|........:||...::...||::|.:.
Human   214 CVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSY 278

  Fly   428 LAYYAEK--LQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALP 490
            ..|.|||  :.::...:|.|....|||.:||:||:||||..|:|:.|..:.:..::..:...|||
Human   279 FVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALP 343

  Fly   491 VPVIVSNFSMFYSHTQARSKLPKKRRR 517
            ..::.|.|::         |:.:|:|:
Human   344 AGILGSGFAL---------KVQQKQRQ 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585
		BTB_2	7..97	CDD:280393
		Ion_trans	307..506	CDD:278921	56/215 (26%)
		Ion_trans_2	<449..499	CDD:285168	18/49 (37%)
KCNQ1	NP_000209.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	62..84		5/31 (16%)
		Ion_trans	153..359	CDD:278921	54/216 (25%)
		Ion_trans_2	270..349	CDD:285168	26/78 (33%)
		Selectivity filter. /evidence=ECO:0000250	312..317		3/4 (75%)
		Interaction with CALM. /evidence=ECO:0000269|PubMed:25441029	370..382
		KCNQ_channel	<511..617	CDD:281513
		Interaction with CALM, calcium-dependent. /evidence=ECO:0000269|PubMed:25441029	515..529
		Interaction with KCNE1 C-terminus. /evidence=ECO:0000269|PubMed:25037568	535..572
		Interaction with AKAP9. /evidence=ECO:0000269|PubMed:11799244	588..616
		C-terminal assembly domain. /evidence=ECO:0000269|PubMed:10654932	589..620
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	620..676

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810