DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and KCNK3

DIOPT Version :10

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_002237.1 Gene:KCNK3 / 3777 HGNCID:6278 Length:394 Species:Homo sapiens


Alignment Length:490 Identity:91/490 - (18%)
Similarity:151/490 - (30%) Gaps:186/490 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   274 QRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYG-----QPHEAFFYVELVCNVWFFIEVI 333
            :||||          |..::::.......:.|:.|...     :||:|........:.:|.|.||
Human    37 ERQRL----------ELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVI 91

  Fly   334 IRL---IVSPN---------LWQFIKSPVNIIDFTATLSFYTDVMQRMGEYTGLLEAFSIVRIMR 386
            ..:   ..:|:         .:..:..|:.::.|           |.:||           ||..
Human    92 TTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMF-----------QSLGE-----------RINT 134

  Fly   387 LFKLTRHSPGLRILIHTFK---------ASAKELTLLVFF-----LVLGIVFFASL-------AY 430
            |         :|.|:|..|         .|...:.|:.||     |.:|...|:..       ||
Human   135 L---------VRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAY 190

  Fly   431 YAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDV-------APKTYPGMFV--GALCALAGVLT 486
            |                    :..:|:||:|:||.       |.:|.| .:|  ..:..|.|:..
Human   191 Y--------------------YCFITLTTIGFGDYVALQKDQALQTQP-QYVAFSFVYILTGLTV 234

  Fly   487 IALPVPVIVSNFSMFYSHTQARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGL 551
            |...:.::|..|....:..:.|.                      |.||..             |
Human   235 IGAFLNLVVLRFMTMNAEDEKRD----------------------AEHRAL-------------L 264

  Fly   552 VAGGVVPVGAGGPGLGGH----AVGHSAAGAPMFKDAFGGAKIGTVNVNGVNVIGLHPAQRTTTT 612
            ...|  ..|.||.|...|    |...:|||...|::.:  |::            || .|...:.
Human   265 TRNG--QAGGGGGGGSAHTTDTASSTAAAGGGGFRNVY--AEV------------LH-FQSMCSC 312

  Fly   613 MAMAMNEADPTPMSALTYQVPMLQP--TPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASA 675
            :.....|       .|.|.:||:.|  ..|.......:|....|.|..|...:.....:|:..||
Human   313 LWYKSRE-------KLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSA 370

  Fly   676 AVATAAAAAPAGPSFISSDYLSVPAVQSLQPRAAT 710
            .            |.:|:...|:...:.|..|.::
Human   371 I------------SSVSTGLHSLSTFRGLMKRRSS 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723
Ion_trans 307..506 CDD:459842 46/245 (19%)
KCNK3NP_002237.1 Ion_trans_2 <73..132 CDD:462301 11/80 (14%)
Selectivity filter 1. /evidence=ECO:0000305|PubMed:26919430 93..98 0/4 (0%)
Ion_trans_2 167..243 CDD:462301 19/96 (20%)
Selectivity filter 2. /evidence=ECO:0000305|PubMed:26919430 199..204 2/4 (50%)
X-gate. /evidence=ECO:0000269|PubMed:32499642 243..248 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..286 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 338..357 4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

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