Protein Alignment Shawl and KCNK1

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_002236.1
• Gene: KCNK1 / 3775
• HGNCID: 6272
• Length: 336
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 69/300 - (23%)
• Similarity: 112/300 - (37%)
• Gaps: 85/300 - (28%)

  Fly   245 FRVTNYTSY-SSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIE 308
            |.|..|..| ..|....|....|...:...:.::|||        .|:||    |....:....:
Human    25 FLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKR--------RFLEE----HECLSEQQLEQ 77

  Fly   309 TYGQPHEAFFY-VELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMG-E 371
            ..|:..||..| |.::.|            .|.| |.:        |||:.|.|.:.|:...| .
Human    78 FLGRVLEASNYGVSVLSN------------ASGN-WNW--------DFTSALFFASTVLSTTGYG 121

  Fly   372 YTGLL----EAFSI------VRIMRLF------KLTRHSPGLRIL-IHTFKASAKELTLLVFFLV 419
            :|..|    :||.|      :....||      ::|.|.....:| .|.....:|::..:|..::
Human   122 HTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVL 186

  Fly   420 LGIV-----FFASLAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAP-KTYPGMF---- 474
            ||.|     ||...|.:: .|:|  |..|..   ..::..::::|:|.||..| :.|...|
Human   187 LGFVTVSCFFFIPAAVFS-VLED--DWNFLE---SFYFCFISLSTIGLGDYVPGEGYNQKFRELY 245

  Fly   475 -VGALC-ALAGVLTIALPVPVIVSNF----------SMFY 502
             :|..| .|.|::.:.    |::..|          .|||
Human   246 KIGITCYLLLGLIAML----VVLETFCELHELKKFRKMFY 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723
		Ion_trans	307..506	CDD:459842	54/236 (23%)
KCNK1	NP_002236.1	Ion_trans_2	<98..157	CDD:462301	16/67 (24%)
		pore-forming domain	107..123		4/15 (27%)
		Ion_trans_2	191..267	CDD:462301	19/85 (22%)
		pore-forming domain	212..238		6/28 (21%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269|PubMed:19959478	293..299