Protein Alignment Shawl and KCNF1

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_002227.2
• Gene: KCNF1 / 3754
• HGNCID: 6246
• Length: 494
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 171/619 - (27%)
• Similarity: 244/619 - (39%)
• Gaps: 203/619 - (32%)

  Fly     7 IILNVSGIRYETYKATLKKIPATRLSRLTEALA-----------NYDPVLNEYFFDRHPGVFTQI 60
            |::||.|:|...|...|.:.|.|||:.|...||           :|||...|::|||.|..|..:
Human    25 IVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCV 89

  Fly    61 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLA-----ILDKLDI 120
            :..|..|::|....:|...|:.|::||.:|...::.||.|..|..|:....:|     |||.|.:
Human    90 IEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGV 154

  Fly   121 ENEKPTEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVIS 185
            :                  .:.|.   |:|.:..:|...::|.||..|::||.:|...|.||.:.
Human   155 D------------------AAEGR---WRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVV 198

  Fly   186 FCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNY 250
            .|:.|.|..:|      .||.|
Human   199 MCMGTIPELQV------LDAEG------------------------------------------- 214

  Fly   251 TSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHE 315
                                                             .|.:|..:|.
Human   215 -------------------------------------------------NRVEHPTLEN------ 224

  Fly   316 AFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY-----TDVMQRMGEYTGL 375
                ||..|..||.:|.::||..|||...|..|.:||:|..|.|.||     |.:..||.|.|.:
Human   225 ----VETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNV 285

  Fly   376 ---LEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQD 437
               ::|..|:||.|:|||.|||.||:.|.:..|.|.|||.||:.:|.:||..|::|.|..|  |.
Human   286 QQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTME--QS 348

  Fly   438 NPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFY 502
            :|:..|||||...||||:|||||||||:.|||..|....|:..|.||:.||||:..|::||..:|
Human   349 HPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYY 413

  Fly   503 SHTQARSKLPKKRRRVLPVEQPRRKREPTAPH-------------RGRTNA----IKQTPPTGPG 550
            :           ::|||         |..|.|             .|:|..    :...||.
Human   414 N-----------KQRVL---------ETAAKHELELMELNSSSGGEGKTGGSRSDLDNLPPE--- 455

  Fly   551 LVAGGVVPVGAGGPGLGGH-AVGHSAAGAPMFKD 583
                   |.|...|..... .:.||....|:..:
Human   456 -------PAGKEAPSCSSRLKLSHSDTFIPLLTE 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	38/123 (31%)
		Ion_trans	307..506	CDD:459842	90/206 (44%)
KCNF1	NP_002227.2	BTB_POZ_Kv5_KCNF1	23..138	CDD:349690	37/112 (33%)
		Ion_trans	181..417	CDD:459842	106/356 (30%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	433..469		7/45 (16%)