DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and KCND1

DIOPT Version :10

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_004970.3 Gene:KCND1 / 3750 HGNCID:6237 Length:647 Species:Homo sapiens


Alignment Length:562 Identity:176/562 - (31%)
Similarity:251/562 - (44%) Gaps:140/562 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRTG 67
            |:..:::||||.|:||:|.||.:.|.|.|.. :|....||....||||||.|.:|..:||:||||
Human    38 GDEVLVVNVSGRRFETWKNTLDRYPDTLLGS-SEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTG 101

  Fly    68 KLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIEN-EKPTEEQIA 131
            :||.|...|...|:|||.|:||....|..||...|   ||.:.          || |:..|::.|
Human   102 RLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEY---RDRKK----------ENAERLAEDEEA 153

  Fly   132 RLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRV 196
            ...|...||..|     ..::.::|..|:.|.:||.|.:...::.|||.||||:..::|.|    
Human   154 EQAGDGPALPAG-----SSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIP---- 209

  Fly   197 DLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTAS 261
                                                                             
Human   210 ----------------------------------------------------------------- 209

  Fly   262 GQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNV 326
                    .:|..|:..:....|                       |.:.|   |||.::..|.:
Human   210 --------CRGSARRSSREQPCG-----------------------ERFPQ---AFFCMDTACVL 240

  Fly   327 WFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVM-QRMGEYTGLLEAFSIVRIMRLFKL 390
            .|..|.::||..:|:..:|::|.:::||..|.|.:|..:: .:..:.:|......:.|:.|:||.
Human   241 IFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVFRIFKF 305

  Fly   391 TRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIPLGLWWAIV 455
            :|||.|||||.:|.|:.|.||..|:|.|.:.|:.||::.:|||| ..|..| |.|||...|:.||
Human   306 SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEK-GTNKTN-FTSIPAAFWYTIV 368

  Fly   456 TMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRRVLP 520
            ||||:||||:.|.|..|...|::|:|:|||.|||||||||||||..|...|...|     ||   
Human   369 TMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADK-----RR--- 425

  Fly   521 VEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAG 562
            .:|..|.........|.|||..|....      ||:...|:|
Human   426 AQQKVRLARIRLAKSGTTNAFLQYKQN------GGLEDSGSG 461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723 47/110 (43%)
Ion_trans 307..506 CDD:459842 86/199 (43%)
KCND1NP_004970.3 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
BTB_POZ 6..143 CDD:453885 48/118 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..163 5/18 (28%)
Ion_trans 185..417 CDD:459842 99/336 (29%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377 3/4 (75%)
DUF3399 470..550 CDD:463381
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..531
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..634
Blue background indicates that the domain is not in the aligned region.

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