Protein Alignment Shawl and KCNC4

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: XP_024302558.1
• Gene: KCNC4 / 3749
• HGNCID: 6236
• Length: 661
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 226/592 - (38%)
• Similarity: 304/592 - (51%)
• Gaps: 146/592 - (24%)

  Fly     2 DGENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLN---------------EYFFD 51
            :...:||:||.|.|:|||::||:.:|.|||:.|.:......|..:               |:|||
Human    33 EASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97

  Fly    52 RHPGVFTQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILD 116
            ||||||..:||||||||||.|.|||||||||||.|||:|...||||||.||..|||.:..|.|.:
Human    98 RHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFE 162

  Fly   117 KLD--IENEKPTEE--------QIARL----FGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTG 167
            ..|  .....|::|        .:.||    .|......:|....||   |::||:|::|.||..
Human   163 SPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQ---PRMWALFEDPYSSRA 224

  Fly   168 AKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQH 232
            |::||..|:|||.||:.:|||:||..|.:|
Human   225 ARVVAFASLFFILVSITTFCLETHEAFNID----------------------------------- 254

  Fly   233 SITPPSGSIGPTFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILG 297
                  .::....||.|.||.   :|....:..||.|
Human   255 ------RNVTEILRVGNITSV---HFRREVETEPILT---------------------------- 282

  Fly   298 HNGRRKHGWIETYGQPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY 362
                                 |:|.||.:||.:|.::|::..|:...|:|:.:|||||.|.|.||
Human   283 ---------------------YIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFY 326

  Fly   363 TDV------MQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLG 421
            .:|      .:...:..|.|.....|||:|:||||||..|||:|.||.:||..|..||:.||.||
Human   327 LEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 391

  Fly   422 IVFFASLAYYAEKL-------QDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALC 479
            ::.||::.||||::       :.|....||:||:|.|||:|||||:||||:.|||:.||.|||||
Human   392 VLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALC 456

  Fly   480 ALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRRVLP----VEQPRR-KREPTAPHRGRTN 539
            |||||||||:||||||:||.|:||...|:.||||||::.:|    :|.|.. |.|.|:|   |.:
Human   457 ALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSP---RDS 518

  Fly   540 AIKQTPP 546
            ....|.|
Human   519 TCSDTSP 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	65/125 (52%)
		Ion_trans	307..506	CDD:459842	102/211 (48%)
KCNC4	XP_024302558.1	Potassium_chann	1..29	CDD:431870
		BTB_KCNC2_4	35..158	CDD:349722	64/122 (52%)
		Ion_trans	225..483	CDD:459842	127/350 (36%)