| Sequence 1: | NP_001097131.2 | Gene: | Shawl / 5740840 | FlyBaseID: | FBgn0085395 | Length: | 937 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_004968.2 | Gene: | KCNC3 / 3748 | HGNCID: | 6235 | Length: | 757 | Species: | Homo sapiens |
| Alignment Length: | 799 | Identity: | 277/799 - (34%) |
|---|---|---|---|
| Similarity: | 368/799 - (46%) | Gaps: | 228/799 - (28%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 6 RIILNVSGIRYETYKATLKKIPATRLSRLTE----ALANYDPVLNEYFFDRHPGVFTQILNYYRT 66
Fly 67 GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPT----- 126
Fly 127 ------------EEQIARLFGFEEALSNGELN--C----------------------WQRIKPKI 155
Fly 156 WAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPM 220
Fly 221 GEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGS 285
Fly 286 ILNEFIEEKILGHNGRRKHGWIETYGQPHEAFF-YVELVCNVWFFIEVIIRLIVSPNLWQFIKSP 349
Fly 350 VNIIDFTATLSFYTDV------MQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASA 408
Fly 409 KELTLLVFFLVLGIVFFASLAYYAEKLQDNPDN-------QFKSIPLGLWWAIVTMTTVGYGDVA 466
Fly 467 PKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRRVLP-VEQPRRKR-- 528
Fly 529 -------EPTAPHRGRTNAIKQTPPTGP---GLVAGGVVPVGA-GGPGLGGHAVGHSAAGAPMFK 582
Fly 583 DAFGGAKIGTVNVNGVNVIGLHPAQRTTTTMAMA------MNEADPTP-----MSALTYQ----- 631
Fly 632 -VPMLQP---TPTPAHSHGHAHGHAHGLGPASAAMTSSA-SLTGSAASAAVATAAA----AAPAG 687
Fly 688 PSFISSDYLSVPAVQSLQP 706 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Shawl | NP_001097131.2 | BTB | 7..99 | CDD:197585 | 60/95 (63%) |
| BTB_2 | 7..97 | CDD:280393 | 59/93 (63%) | ||
| Ion_trans | 307..506 | CDD:278921 | 109/212 (51%) | ||
| Ion_trans_2 | <449..499 | CDD:285168 | 39/49 (80%) | ||
| KCNC3 | NP_004968.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..87 | ||
| Important for normal N-type inactivation. /evidence=ECO:0000269|PubMed:26997484 | 1..78 | ||||
| Potassium_chann | 1..>18 | CDD:314363 | |||
| BTB_KCNC1_3 | 89..202 | CDD:349721 | 68/112 (61%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 210..232 | 2/21 (10%) | |||
| Ion_trans | 289..550 | CDD:366146 | 131/351 (37%) | ||
| Selectivity filter. /evidence=ECO:0000250 | 503..508 | 3/4 (75%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 556..613 | 16/57 (28%) | |||
| PHA03247 | <637..752 | CDD:223021 | 27/121 (22%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 682..746 | 17/68 (25%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 254 | 1.000 | Domainoid score | I2063 |
| eggNOG | 1 | 0.900 | - | - | E1_COG2126 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 460 | 1.000 | Inparanoid score | I1570 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D331021at33208 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 1 | 1.100 | - | - | O | PTHR11537 |
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X19 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 9 | 9.020 | |||||