DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shawl and KCNC2

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_631875.1	Gene:	KCNC2 / 3747	HGNCID:	6234	Length:	638	Species:	Homo sapiens

Alignment Length:	590	Identity:	227/590 - (38%)
Similarity:	306/590 - (51%)	Gaps:	165/590 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDGENRIILNVSGIRYETYKATLKKIPATRLSRLT-------------EALANYDPVLN------ 46
            ::...|:||||.|.|:|||::|||.:|.|||:.|.             :.|....|.|:
Human     4 IENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAP 68

  Fly    47 --------------------------------EYFFDRHPGVFTQILNYYRTGKLHYPTDVCGPL 79
                                            |:|||||||||..:||||||||||.|.||||||
Human    69 PLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPL 133

  Fly    80 FEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKP--TEEQIARLFGFEEALS- 141
            |||||.|||:|...||||||.||..|||.:..|.|.:..|:....|  .|:..|:..|.|:|..
Human   134 FEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAKRLGIEDAAGL 198

  Fly   142 ---NGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPSGAH 203
               :|:...|:|::|::||:|::|.||..|:.:|..|:|||.||:.:|||:||..|.:
Human   199 GGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNI------- 256

  Fly   204 DAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQATPIA 268
                                                       |.|.|.             |:
Human   257 -------------------------------------------VKNKTE-------------PV- 264

  Fly   269 TIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWFFIEVI 333
                         |||:.:       :|.:.       |||    ..|..|||.||.|||..|.:
Human   265 -------------INGTSV-------VLQYE-------IET----DPALTYVEGVCVVWFTFEFL 298

  Fly   334 IRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV------MQRMGEYTGLLEAFSIVRIMRLFKLTR 392
            :|::.|||..:|||:.:|||||.|.|.||.:|      .:...:..|.|.....|||:|:|||||
Human   299 VRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTR 363

  Fly   393 HSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDN-------QFKSIPLGL 450
            |..|||:|.||.:||..|..||:.||.||::.||::.||||::...|::       |||:||:|.
Human   364 HFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGF 428

  Fly   451 WWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKR 515
            |||:|||||:||||:.|:|:.||.||||||||||||||:||||||:||.|:||...|:.|||:||
Human   429 WWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKR 493

  Fly   516 RRVLP 520
            ::.:|
Human   494 KKHIP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	60/142 (42%)
		BTB_2	7..97	CDD:280393	58/140 (41%)
		Ion_trans	307..506	CDD:278921	111/211 (53%)
		Ion_trans_2	<449..499	CDD:285168	38/49 (78%)
KCNC2	NP_631875.1	BTB_KCNC2_4	7..166	CDD:349722	68/158 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..93		3/54 (6%)
		Ion_trans	228..484	CDD:395416	133/350 (38%)
		Selectivity filter. /evidence=ECO:0000250	437..442		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	254	1.000	Domainoid score	I2063
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1570
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	1	1.000	-	-		FOG0000990
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.930