Protein Alignment Shawl and KCNC1

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_001106212.1
• Gene: KCNC1 / 3746
• HGNCID: 6233
• Length: 585
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 228/572 - (39%)
• Similarity: 307/572 - (53%)
• Gaps: 135/572 - (23%)

  Fly     2 DGENRIILNVSGIRYETYKATLKKIPATRLSRLTEALA----NYDPVLNEYFFDRHPGVFTQILN 62
            |...||::||.|.|::||::||:.:|.|||:.|.|..|    :|||..:|:|||||||||..|||
Human     5 DESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILN 69

  Fly    63 YYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTL-----AILDKL--DI 120
            ||||||||.|.||||||:||||.|||:|...||||||.||..|||.:..|     |.||..  |.
Human    70 YYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDA 134

  Fly   121 ENEKP-------TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFF 178
            :.:.|       .|.::.:.....::........|:|.:|:|||:|::|.||..|:.||..|:||
Human   135 DADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFF 199

  Fly   179 IFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGP 243
            |.||:.:|||:||..|                       :|
Human   200 ILVSITTFCLETHERF-----------------------NP------------------------ 217

  Fly   244 TFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIE 308
               :.|              .|.|..::.|.:.|..|.                         .|
Human   218 ---IVN--------------KTEIENVRNGTQVRYYRE-------------------------AE 240

  Fly   309 TYGQPHEAFF-YVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV------M 366
            |     |||. |:|.||.|||..|.::|:|..||..:|||:.:|||||.|.|.||.:|      .
Human   241 T-----EAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSS 300

  Fly   367 QRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYY 431
            :...:..|.|.....|||:|:||||||..|||:|.||.:||..|..||:.||.||::.||::.||
Human   301 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYY 365

  Fly   432 AEKLQDNPDN-------QFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIAL 489
            ||::...|::       .||:||:|.|||:|||||:||||:.|:|:.||.||||||||||||||:
Human   366 AERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAM 430

  Fly   490 PVPVIVSNFSMFYSHTQARSKLPKKRRRVLPVEQPRRKREP-------TAPH 534
            ||||||:||.|:||...|:.|||||:::.:|  :|.:...|       .:||
Human   431 PVPVIVNNFGMYYSLAMAKQKLPKKKKKHIP--RPPQLGSPNYCKSVVNSPH 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	69/119 (58%)
		Ion_trans	307..506	CDD:459842	110/212 (52%)
KCNC1	NP_001106212.1	BTB_KCNC1_3	6..122	CDD:349721	68/115 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..147		5/25 (20%)
		Ion_trans	189..447	CDD:459842	132/351 (38%)
		Selectivity filter. /evidence=ECO:0000250	400..405		3/4 (75%)