Protein Alignment Shawl and KCNB1

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_004966.1
• Gene: KCNB1 / 3745
• HGNCID: 6231
• Length: 858
• Species: Homo sapiens
• Alignment Length: 966
• Identity: 251/966 - (25%)
• Similarity: 372/966 - (38%)
• Gaps: 293/966 - (30%)

  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVL----------NEYFFDRHPGVFTQI 60
            |:.|||.|:.:|....||.::|.|||.:|.:. ..:|.:|          ||||||||||.||.|
Human    32 RVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDC-NTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSI 95

  Fly    61 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKP 125
            ||:||||:||...::|...|.:||::||:|...:|.||.:.|...::..|     ::|..|.|..
Human    96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMN-----EELKREAETL 155

  Fly   126 TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKT 190
            .|.:       .|...|   .|....:.|:|.:.::|:||..|||:|.:|:.||.:|.|:..|.|
Human   156 RERE-------GEEFDN---TCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNT 210

  Fly   191 HPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSS 255
            .|..:      :.|..|.....|...|
Human   211 LPELQ------SLDEFGQSTDNPQLAH-------------------------------------- 231

  Fly   256 GNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYV 320
                                                                            |
Human   232 ----------------------------------------------------------------V 232

  Fly   321 ELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGLLE 377
            |.||..||.:|.::|.:.||..|:|.|.|:|.||..|.|.:|..:        :.:......:::
Human   233 EAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQ 297

  Fly   378 AFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQ 442
            .|.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |..|.:
Human   298 IFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDDTK 360

  Fly   443 FKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQA 507
            |||||...|||.:|||||||||:.|||..|..||.||.:||||.||||:|:||:|||.||.. |.
Human   361 FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-QK 424

  Fly   508 RSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAGGPGLGGHAVG 572
            |.:...|||..|    .|.||.                        |.:|.:.
Human   425 RQEKAIKRREAL----ERAKRN------------------------GSIVSMN------------ 449

  Fly   573 HSAAGAPMFKDAFGGAKIGTVNV----NGVNVIGLHPAQRTTTTMAMAMNEADPTPMSALTYQVP 633
                    .|||| ...|..:::    ||.|                 |.:.|..
Human   450 --------MKDAF-ARSIEMMDIVVEKNGEN-----------------MGKKDKV---------- 478

  Fly   634 MLQPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASAAVATAAAAAP-AGPSFISSDYLS 697
                      ...|       |.|.....| ..:|:.:::|.:..|....:| ...|..|..:|:
Human   479 ----------QDNH-------LSPNKWKWT-KRTLSETSSSKSFETKEQGSPEKARSSSSPQHLN 525

  Fly   698 VPAVQSLQPRAATTGHDFML-----PLQPKLLGPLERKDQHPLQLTAHNLASDTHQLMYSGHAHS 757
            |..::.:..:.|.|....:|     ..|.|   |.|..:...:......|.:.|..::   ...|
Human   526 VQQLEDMYNKMAKTQSQPILNTKESAAQSK---PKEELEMESIPSPVAPLPTRTEGVI---DMRS 584

  Fly   758 QHKVGGG-AAVLNVPPTLSMSH---TQMPPGIASMGQRTPNLSFRPAHGASSQVATVQQPIPHSH 818
            ...:... :...:.|.....||   |.:|.  .:.|...|.:.:|.|.|||........|.|.:
Human   585 MSSIDSFISCATDFPEATRFSHSPLTSLPS--KTGGSTAPEVGWRGALGASGGRFVEANPSPDA- 646

  Fly   819 ACHAS-----------TNCNIKISVASAGLSVGCPDEFRTPKVTLL----DDLSDDVNSSTDDCG 868
            :.|:|           ||..:|:.........|.|    :|.:.:|    |.|.:..:::....|
Human   647 SQHSSFFIESPKSSMKTNNPLKLRALKVNFMEGDP----SPLLPVLGMYHDPLRNRGSAAAAVAG 707

  Fly   869 -DCC-LVD------DSDTYEGTTINNGPSGQENGTE-AIGLDDGL---LDNDGEDE 912
             :|. |:|      :|..|...:....|...|..|. |...:.|:   :|.|.:||
Human   708 LECATLLDKAVLSPESSIYTTASAKTPPRSPEKHTAIAFNFEAGVHQYIDADTDDE 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	44/101 (44%)
		BTB_2	7..97	CDD:280393	43/99 (43%)
		Ion_trans	307..506	CDD:278921	92/206 (45%)
		Ion_trans_2	<449..499	CDD:285168	32/49 (65%)
KCNB1	NP_004966.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		BTB_POZ_KCNB2	15..141	CDD:349719	47/109 (43%)
		Self-association. /evidence=ECO:0000250|UniProtKB:P15387	59..75		3/16 (19%)
		Ion_trans	188..424	CDD:395416	108/346 (31%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000250|UniProtKB:P15387	448..481		10/90 (11%)
		Kv2channel	467..679	CDD:397541	46/265 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..524		13/97 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..574		7/38 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	770..807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	836..858

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810