DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and KCNA10

DIOPT Version :10

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_005540.1 Gene:KCNA10 / 3744 HGNCID:6219 Length:511 Species:Homo sapiens


Alignment Length:563 Identity:167/563 - (29%)
Similarity:258/563 - (45%) Gaps:165/563 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DGENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT 66
            :|..|:|:|::|:|:||...||.:.|.|.|....:.:..:|.:.|||||||:...|..||.||::
Human    83 EGNQRVIINIAGLRFETQLRTLSQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQS 147

  Fly    67 -GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQI 130
             ||:..|.:|...:|.:|:.|:.|.|..::.        .|:.:..:.     |.|...||.:  
Human   148 GGKIRRPANVPIDIFADEISFYELGSEAMDQ--------FREDEGFIK-----DPETLLPTND-- 197

  Fly   131 ARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFR 195
                                |..:.|.:|:.|.||:.|:.||.:||..:.:|:..|||:|.|.||
Human   198 --------------------IHRQFWLLFEYPESSSAARAVAVVSVLVVVISITIFCLETLPEFR 242

  Fly   196 VDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTA 260
            .|                                                               
Human   243 ED--------------------------------------------------------------- 244

  Fly   261 SGQATPIATIKGGQRQRLK------RNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFY 319
                           :.||      .|::.::|::.:                  :..|   ||.
Human   245 ---------------RELKVVRDPNLNMSKTVLSQTM------------------FTDP---FFM 273

  Fly   320 VELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGEYT----------G 374
            ||..|.|||..|:::|.:|.|:...|.::.:||||..:.:.::..::..:.:.|          .
Human   274 VESTCIVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLA 338

  Fly   375 LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNP 439
            :|....:||:.|:|||:|||.||:||..|.|||.:||.||:|||.:|::.|:|..|:||  .|.|
Human   339 ILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--VDEP 401

  Fly   440 DNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFY-- 502
            ::.|.|||.|.|||:||||||||||:.|.|..|..||.|||:|||||||||||||||||:.||  
Human   402 ESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHR 466

  Fly   503 -SHTQARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQT 544
             :..:.:..:|.:..|:|         .......|.|:::.:|
Human   467 ETENEEKQNIPGEIERIL---------NSVGSRMGSTDSLNKT 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723 35/111 (32%)
Ion_trans 307..506 CDD:459842 97/211 (46%)
KCNA10NP_005540.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..50
BTB_POZ_KCNA10 86..172 CDD:349716 32/85 (38%)
Ion_trans 255..467 CDD:459842 99/234 (42%)
Selectivity filter. /evidence=ECO:0000250 421..426 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 489..511 3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

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