DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and KCNA6

DIOPT Version :9

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_002226.1 Gene:KCNA6 / 3742 HGNCID:6225 Length:529 Species:Homo sapiens


Alignment Length:581 Identity:188/581 - (32%)
Similarity:274/581 - (47%) Gaps:155/581 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69
            |:::|:||:|:||...||...|.|.|......:..:||:.|||||||:...|..||.||:: |:|
Human    42 RLVINISGLRFETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 106

  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134
            ..|.:|...:|.||:.|:.|....:        :..|:.:..|    ....|:|||...|     
Human   107 RRPVNVPLDIFLEEIRFYQLGDEAL--------AAFREDEGCL----PEGGEDEKPLPSQ----- 154

  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199
                        .:||   ::|.:|:.|.||..|:.:|.:||..|.:|::.|||:|.|.||||  
Human   155 ------------PFQR---QVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRVD-- 202

  Fly   200 SGAHDAHGPGAGGPPHG---HDPMGEPPQ--------THQYHQHSITPPSGSIGPTFRVTNYTSY 253
                     |.||...|   ..|:....|        ::.:| |.|||  |.:|           
Human   203 ---------GRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFH-HGITP--GEMG----------- 244

  Fly   254 SSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFF 318
                   :|.::.::|            :.||...                          :.||
Human   245 -------TGGSSSLST------------LGGSFFT--------------------------DPFF 264

  Fly   319 YVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRM--------GE 371
            .||.:|.|||..|:::|....|:...|.::.:||||..|...::    |:::|:.        |.
Human   265 LVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIIDLVAIFPYFITLGTELVQQQEQQPASGGGG 329

  Fly   372 YTG-------LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLA 429
            ..|       :|....:||:.|:|||:|||.||:||..|.:||.:||.||:|||.:|::.|:|..
Human   330 QNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAV 394

  Fly   430 YYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVI 494
            |:||  .|:.|:.|.|||...|||:||||||||||:.|.|..|..||:|||:|||||||||||||
Human   395 YFAE--ADDDDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVI 457

  Fly   495 VSNFSMF------------YSHTQARSKLPKKRRRVLPVEQP-----RRKREPT---APHR 535
            ||||:.|            |:|.......|..|.....:.:|     .|:|.|:   .|||
Human   458 VSNFNYFYHRETEQEEQGQYTHVTCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHR 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB 7..99 CDD:197585 34/92 (37%)
BTB_2 7..97 CDD:280393 34/90 (38%)
Ion_trans 307..506 CDD:278921 98/229 (43%)
Ion_trans_2 <449..499 CDD:285168 37/49 (76%)
KCNA6NP_002226.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
BTB_POZ_KCNA6 41..170 CDD:349714 47/159 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..233 3/22 (14%)
Ion_trans 258..468 CDD:366146 96/237 (41%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 360..373 6/12 (50%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 422..427 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..513 5/24 (21%)
PDZ-binding. /evidence=ECO:0000255 527..529
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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