DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and KCNA4

DIOPT Version :9

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_002224.1 Gene:KCNA4 / 3739 HGNCID:6222 Length:653 Species:Homo sapiens


Alignment Length:529 Identity:177/529 - (33%)
Similarity:247/529 - (46%) Gaps:155/529 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69
            |:::||||:|:||...||.:.|.|.|....:....:||:.|||||||:...|..||.||:: |:|
Human   177 RVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 241

  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134
            ..|.:|...:|.||::|:.|...                    |:|...:.|.....||      
Human   242 KRPVNVPFDIFTEEVKFYQLGEE--------------------ALLKFREDEGFVREEE------ 280

  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVD-- 197
              :.||...|      .|.:||.:|:.|.||:.|:.:|.:||..|.:|::.|||:|.|.||.|  
Human   281 --DRALPENE------FKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRD 337

  Fly   198 ----LPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNF 258
                |.:|.|                                                       
Human   338 LVMALSAGGH------------------------------------------------------- 347

  Fly   259 TASGQATPIATIKGGQRQRLKRNINGSILNE----FIEEKILGHNGRRKHGWIETYGQPHEAFFY 319
                                     |.:||:    .:|..  ||.         .:..|   ||.
Human   348 -------------------------GGLLNDTSAPHLENS--GHT---------IFNDP---FFI 373

  Fly   320 VELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGEYTG------ 374
            ||.||.|||..|.::|....|:...|.|:.:||||..:.|.::    ||:.|:.|...|      
Human   374 VETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAM 438

  Fly   375 ---LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQ 436
               :|....:||:.|:|||:|||.||:||.||.:||.:||.||:|||.:|::.|:|..|:||  .
Human   439 SFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAE--A 501

  Fly   437 DNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMF 501
            |.|...|:|||...|||:||||||||||:.|.|..|..||:|||:|||||||||||||||||:.|
Human   502 DEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYF 566

  Fly   502 YSHTQARSK 510
            | |.:..::
Human   567 Y-HRETENE 574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB 7..99 CDD:197585 35/92 (38%)
BTB_2 7..97 CDD:280393 35/90 (39%)
Ion_trans 307..506 CDD:278921 103/211 (49%)
Ion_trans_2 <449..499 CDD:285168 37/49 (76%)
KCNA4NP_002224.1 K_channel_TID 1..>37 CDD:400339
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..148
BTB_POZ 176..303 CDD:365784 49/159 (31%)
Ion_trans 306..570 CDD:395416 126/360 (35%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 462..475 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 524..529 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..653
PDZ-binding. /evidence=ECO:0000250 651..653
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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