Protein Alignment Shawl and KCNA3

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_002223.3
• Gene: KCNA3 / 3738
• HGNCID: 6221
• Length: 575
• Species: Homo sapiens
• Alignment Length: 510
• Identity: 168/510 - (32%)
• Similarity: 246/510 - (48%)
• Gaps: 135/510 - (26%)

  Fly     3 GENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT- 66
            || |:::|:||:|:||...||.:.|.|.|......:..:||:.|||||||:...|..||.||::
Human   103 GE-RVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSG 166

  Fly    67 GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIA 131
            |::..|.:|...:|.||:.|:.|....:|.        .|:.:..|.       |.|:|...:
Human   167 GRIRRPVNVPIDIFSEEIRFYQLGEEAMEK--------FREDEGFLR-------EEERPLPRR-- 214

  Fly   132 RLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRV 196
                           .:||   ::|.:|:.|.||..|:.:|.:||..|.:|::.|||:|.|.||
Human   215 ---------------DFQR---QVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFR- 260

  Fly   197 DLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTAS 261
                                 |....|..|                           |..:|.|:
Human   261 ---------------------DEKDYPAST---------------------------SQDSFEAA 277

  Fly   262 GQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNV 326
            |.:|                 :||                  .....::..|   ||.||.:|.:
Human   278 GNST-----------------SGS------------------RAGASSFSDP---FFVVETLCII 304

  Fly   327 WFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGE-----YTGLLEAFSIV 382
            ||..|:::|....|:...|.::.:|:||..|.:.::    |::.:|.|.     ...:|....:|
Human   305 WFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLV 369

  Fly   383 RIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIP 447
            |:.|:|||:|||.||:||..|.|||.:||.||:|||.:|::.|:|..|:||  .|:|.:.|.|||
Human   370 RVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--ADDPTSGFSSIP 432

  Fly   448 LGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFY 502
            ...|||:||||||||||:.|.|..|..||:|||:|||||||||||||||||:.||
Human   433 DAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	34/92 (37%)
		BTB_2	7..97	CDD:280393	34/90 (38%)
		Ion_trans	307..506	CDD:278921	96/205 (47%)
		Ion_trans_2	<449..499	CDD:285168	37/49 (76%)
KCNA3	NP_002223.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		BTB	106..200	CDD:197585	35/101 (35%)
		BTB_2	106..197	CDD:280393	34/98 (35%)
		Ion_trans	290..490	CDD:278921	96/203 (47%)
		Ion_trans_2	404..481	CDD:285168	48/78 (62%)
		Selectivity filter. /evidence=ECO:0000250	444..449		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250	573..575

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810