DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shawl and KCNA2

DIOPT Version :9

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_004965.1 Gene:KCNA2 / 3737 HGNCID:6220 Length:499 Species:Homo sapiens


Alignment Length:510 Identity:168/510 - (32%)
Similarity:245/510 - (48%) Gaps:139/510 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69
            |:::|:||:|:||...||.:.|.|.|....:.:..:||:.|||||||:...|..||.||:: |:|
Human    34 RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 98

  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134
            ..|.:|...:|.||:.|:.|....:|        :.|:.:..:.       |.|:|..|      
Human    99 RRPVNVPLDIFSEEIRFYELGEEAME--------MFREDEGYIK-------EEERPLPE------ 142

  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199
                       |.:||   ::|.:|:.|.||..|:|:|.:||..|.:|::||||:|.|.||.:  
Human   143 -----------NEFQR---QVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDE-- 191

  Fly   200 SGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQA 264
              ..|.||.|.                 .:|.:|    :.:||         ...|.:||     
Human   192 --NEDMHGSGV-----------------TFHTYS----NSTIG---------YQQSTSFT----- 219

  Fly   265 TPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWFF 329
                                                              :.||.||.:|.:||.
Human   220 --------------------------------------------------DPFFIVETLCIIWFS 234

  Fly   330 IEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGE------------YTGLLEAFSIV 382
            .|.::|....|:...|..:.:||||..|.:.::..:...:.|            ...:|....:|
Human   235 FEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLV 299

  Fly   383 RIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIP 447
            |:.|:|||:|||.||:||..|.|||.:||.||:|||.:|::.|:|..|:||  .|..::||.|||
Human   300 RVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--ADERESQFPSIP 362

  Fly   448 LGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFY 502
            ...|||:|:||||||||:.|.|..|..||:|||:|||||||||||||||||:.||
Human   363 DAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB 7..99 CDD:197585 35/92 (38%)
BTB_2 7..97 CDD:280393 35/90 (39%)
Ion_trans 307..506 CDD:278921 93/208 (45%)
Ion_trans_2 <449..499 CDD:285168 36/49 (73%)
KCNA2NP_004965.1 Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142 1..125 36/98 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
BTB_POZ 33..159 CDD:365784 47/159 (30%)
Ion_trans 162..420 CDD:395416 119/347 (34%)
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 312..325 7/12 (58%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 374..379 4/4 (100%)
PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142 497..499
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2126
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.