DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shawl and KCNQ

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_788300.3	Gene:	KCNQ / 36071	FlyBaseID:	FBgn0033494	Length:	993	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	123/572 - (21%)
Similarity:	205/572 - (35%)	Gaps:	143/572 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 FYVELVCNVWFFIEVIIRLIVSPNLW---------------QFIKSPVNIIDFTATLSFYTDVMQ 367
            |.:|::..:||.:|...|      ||               :|:|.|..|||....|:  :.|:.
  Fly   108 FRMEILVVIWFTMEFGAR------LWSSGCRSRYQGCLGRLKFVKRPFCIIDIVTILA--SIVVL 164

  Fly   368 RMGE-----YTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFAS 427
            .||.     .|..|......:|:|:.::.|.....::|.....|..:||...::...||::|.:.
  Fly   165 GMGTSGQVFATSALRGLRFFQILRMVRMDRRGGTWKLLGSVVYAHRQELITTMYIGFLGLIFASF 229

  Fly   428 LAYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVP 492
            |.|..||   :.:::|.:....|||.::|:.||||||:.|.|:.|..:.:.|||.|:...|||..
  Fly   230 LVYMWEK---DVNDKFSNFAQALWWGVITLCTVGYGDMVPITWQGKLIASCCALLGISFFALPAG 291

  Fly   493 VIVSNFSMFYSHTQARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVV 557
            ::.|.|::         |:.:::|:    :...|:|:|.|.                 |:
  Fly   292 ILGSGFAL---------KVQQQQRQ----KHMIRRRQPAAT-----------------LI----- 321

  Fly   558 PVGAGGPGLGGHAV-------GHSAAGAPMFKDAFGGAKIGTVNVNGVNVIGLHPAQRTTTTMAM 615
                       .||       .||.:             :.|.|::.| .:...||.|.:::...
  Fly   322 -----------QAVWRCYAADEHSVS-------------VATWNIHRV-ALPSPPASRASSSFKH 361

  Fly   616 AMNEADPTPMSALTYQVPMLQPTPTPAHSHGHAHGHAHGLGPASAAMTSS-ASLTGSAASAAVAT 679
            ..:.....|    |.:....|...||....|.......|...||...|.: ..:..|..:..|..
  Fly   362 NTSFVARLP----TIRRHKSQTIQTPGGGDGGGVSKPPGSSRASTRYTRTIRDINASVENLEVVQ 422

  Fly   680 AAAAAPAGPSFISSDYLSVPAVQSLQPRAATTGHDFMLPLQPKLLGPLERKDQHPLQLTAHNLAS 744
            ...:  ..|||..........:::::...|:         ||..|...:      |..:|.:||.
  Fly   423 NGKS--MNPSFSEDSVAETTCLKNIKNSDAS---------QPATLANCK------LSSSAGSLAQ 470

  Fly   745 ------DTHQLMYSGH-------AHSQHKVGGGAAVLNVPPTL-SMSHTQMPPGIASMGQRTPNL 795
                  |..| ...||       |..|.|.||....|.:|..| ...|........|:  |.|.:
  Fly   471 FPDRNRDRDQ-DRRGHGEGEGDQAEEQAKAGGSRRNLTIPVVLYGFLHGNFLGSTLSL--RNPRV 532

  Fly   796 SFRPAHGASSQVATVQQPIPHSHACHASTNCNIKISVASAGLSVGCPDEFRT 847
            :  ||:....:....:..: |...|..|....:.:...|..   |.|...||
  Fly   533 A--PANDRDLEAGRDEDEV-HKDTCQRSNTLPLPVKPDSPS---GSPGSGRT 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585
		BTB_2	7..97	CDD:280393
		Ion_trans	307..506	CDD:278921	57/207 (28%)
		Ion_trans_2	<449..499	CDD:285168	21/49 (43%)
KCNQ	NP_788300.3	Ion_trans	100..305	CDD:278921	58/216 (27%)
		Ion_trans_2	221..295	CDD:285168	28/76 (37%)
		KCNQ_channel	<619..719	CDD:281513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439073
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11537
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840