Protein Alignment Shawl and Kcng1

DIOPT Version :10

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_001100015.1
• Gene: Kcng1 / 296395
• RGDID: 631416
• Length: 514
• Species: Rattus norvegicus
• Alignment Length: 554
• Identity: 150/554 - (27%)
• Similarity: 235/554 - (42%)
• Gaps: 171/554 - (30%)

  Fly     2 DGENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVL----------NEYFFDRHPGV 56
            |...:||:||.||:|.....||.:.|.|||.:| :|..|:|.:|          ||:||||:||.
  Rat    60 DRRRQIIINVGGIKYSLPWTTLDEFPLTRLGQL-KACTNFDDILSVCDDYDVTCNEFFFDRNPGA 123

  Fly    57 FTQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTY---------SIHRDTQNTL 112
            |..||.:.|.|||....::|...|:|||.:||:..:.::.||...|         .:.|:.:.
  Rat   124 FGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMMEREDEE-- 186

  Fly   113 AILDKLDIENEKPTEEQIARLFGFEEALSNGELN-CWQRIKPKIWAMFDEPSSSTGAKIVAGMSV 176
            ..||..|.|:|.|             :.|.|.|: |.:|::.    |.::|.|....|:.|.:||
  Rat   187 EALDSEDQESEGP-------------STSEGRLSRCMRRLRD----MVEKPHSGLPGKVFACLSV 234

  Fly   177 FFIFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSI 241
            .|:.|:.::..:.|.|..|.:
  Rat   235 LFVTVTAVNLSVSTLPSLREE-------------------------------------------- 255

  Fly   242 GPTFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGW 306
                             ...||.:.:.                             ||
  Rat   256 -----------------EEQGQCSQMC-----------------------------HN------- 267

  Fly   307 IETYGQPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVM----- 366
                      .|.||.||..||.:|.::|.|.:|:.:.|::||:.:||..|.|.:|..::
  Rat   268 ----------VFIVESVCVGWFSLEFLLRFIQAPSKFAFLRSPLTLIDLVAILPYYVTLLVDGAA 322

  Fly   367 -QRMGEYTG---------LLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLG 421
             .|....||         :|.....:||:.:.:|.|||.||:.|..|.:...:|..||:.||.:.
  Rat   323 SSRRKPSTGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVA 387

  Fly   422 IVFFASLAYYAE-KLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVL 485
            |..||.|.|..| ::.|:|  :|.|||...|||::|||||||||:.|::.||..|.....|:|:|
  Rat   388 IALFAPLLYVIENEMADSP--EFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGIL 450

  Fly   486 TIALPVPVIVSNFSMFYSHTQARSKLPKKRRRVL 519
            .:|.||.      |:|::.:::..:|.:::.|||
  Rat   451 LMAFPVT------SIFHTFSRSYLELKQEQERVL 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	44/129 (34%)
		Ion_trans	307..506	CDD:459842	74/214 (35%)
Kcng1	NP_001100015.1	BTB_POZ_KCNG1_2	60..173	CDD:349728	44/113 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..205		8/38 (21%)
		Ion_trans	227..471	CDD:459842	87/358 (24%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	424..429		4/4 (100%)