Protein Alignment Shawl and KCNV1

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_055194.1
• Gene: KCNV1 / 27012
• HGNCID: 18861
• Length: 500
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 138/539 - (25%)
• Similarity: 218/539 - (40%)
• Gaps: 165/539 - (30%)

  Fly     9 LNVSGIRYETYKATLKKIPATRLSRLTEALANY-------------------DPVLNEYFFDRHP 54
            :||.|.|:...:..|...|.|||.:|...:|:|                   :||.|||||||..
Human    43 VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYFFDRSS 107

  Fly    55 GVFTQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLD 119
            ..|..:|:|||||:||....:|...|.:|:::||:|...::.||...|...::...||..  |.|
Human   108 QAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDF--KKD 170

  Fly   120 IENEKPTEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVI 184
            .|:::...|.       |:..|.|.  | ..::.|:|.:.::|.|||.|:|...:|:.|:.||:|
Human   171 TEDQESQHES-------EQDFSQGP--C-PTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSII 225

  Fly   185 SFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTN 249
            :..|.:
Human   226 NMALMS----------------------------------------------------------- 231

  Fly   250 YTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPH 314
                                                                .:..|::.
Human   232 ----------------------------------------------------AELSWLDL----- 239

  Fly   315 EAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY-------------TDVM 366
            :....:|.||..||..|.::|.:...:..:|::...||||..|.|.||             |..:
Human   240 QLLEILEYVCISWFTGEFVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQEL 304

  Fly   367 QRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYY 431
            :.:|.   :::...::|.:|:.||.|||.|||.|..|.....:|:.||:.||.:||..|:::.|:
Human   305 ENVGR---IVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYF 366

  Fly   432 AEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVS 496
            ||  |..||..|.|:|...|||..:||||||||:.|.|..|..|..:|.|:|:|.:|||:.:|..
Human   367 AE--QSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIIND 429

  Fly   497 NFSMFYSHTQARSKLPKKR 515
            .||..|...:.:....::|
Human   430 RFSACYFTLKLKEAAVRQR 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	37/108 (34%)
		BTB_2	7..97	CDD:280393	36/106 (34%)
		Ion_trans	307..506	CDD:278921	73/211 (35%)
		Ion_trans_2	<449..499	CDD:285168	23/49 (47%)
KCNV1	NP_055194.1	BTB_POZ	41..160	CDD:365784	39/116 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..189		7/29 (24%)
		Ion_trans	209..435	CDD:366146	81/346 (23%)
		Selectivity filter. /evidence=ECO:0000250	392..397		4/4 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820