Protein Alignment Shawl and KCNG2

DIOPT Version :9

• Sequence 1: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: XP_016881193.1
• Gene: KCNG2 / 26251
• HGNCID: 6249
• Length: 509
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 148/578 - (25%)
• Similarity: 220/578 - (38%)
• Gaps: 177/578 - (30%)

  Fly     7 IILNVSGIRYETYKATLKKIPATRLSR---------LTEALANYDPVLNEYFFDRHPGVFTQILN 62
            :|:||.|.|.....|.|.:.|..||.|         |.....:||...:|:||||.|..|..|:.
Human    62 VIINVGGCRVRLAWAALARCPLARLERLRACRGHDDLLRVCDDYDVSRDEFFFDRSPCAFRAIVA 126

  Fly    63 YYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEK--- 124
            ..|.|||......|...|.:||.:||:|..::|.||                |.:|....|:
Human   127 LLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCC----------------LRRLRRREEEAAE 175

  Fly   125 ----PTEE----QIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFV 181
                |||.    ..||..|     ..|.|   ||.:.::..:.|.|.|....|:.|.:||.|:.|
Human   176 ARAGPTERGAQGSPARALG-----PRGRL---QRGRRRLRDVVDNPHSGLAGKLFACVSVSFVAV 232

  Fly   182 SVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFR 246
            :.:..||.|.|..|.:                                      ...|...|..|
Human   233 TAVGLCLSTMPDIRAE--------------------------------------EERGECSPKCR 259

  Fly   247 VTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYG 311
                                                                             
Human   260 ----------------------------------------------------------------- 259

  Fly   312 QPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY-------------T 363
                :.|.:|.||..||..|.::|.:.:.:...|:::|:||||..|.|.||             |
Human   260 ----SLFVLETVCVAWFSFEFLLRSLQAESKCAFLRAPLNIIDILALLPFYVSLLLGLAAGPGGT 320

  Fly   364 DVMQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASL 428
            .:::|.|....||.|..::.:||   |.|||.|||.|..|.:..|:|..||:.||.:.:..||.|
Human   321 KLLERAGLVLRLLRALRVLYVMR---LARHSLGLRSLGLTMRRCAREFGLLLLFLCVAMALFAPL 382

  Fly   429 AYYAEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPV 493
            .:.||: :......|.|:|...|||:::||||||||:.|::.||..|.....|:|:|.:|.||.
Human   383 VHLAER-ELGARRDFSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVT- 445

  Fly   494 IVSNFSMFYSHTQARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGL 551
                 |:|::.:::.|:|.::::|....| |..:.:.|  |...........|...||
Human   446 -----SIFHTFSRSYSELKEQQQRAASPE-PALQEDST--HSATATEDSSQGPDSAGL 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	35/100 (35%)
		BTB_2	7..97	CDD:280393	34/98 (35%)
		Ion_trans	307..506	CDD:278921	72/211 (34%)
		Ion_trans_2	<449..499	CDD:285168	21/49 (43%)
KCNG2	XP_016881193.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D818306at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820