DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shawl and Kcnb1

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_037318.2	Gene:	Kcnb1 / 25736	RGDID:	2954	Length:	857	Species:	Rattus norvegicus

Alignment Length:	961	Identity:	251/961 - (26%)
Similarity:	369/961 - (38%)	Gaps:	284/961 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVL----------NEYFFDRHPGVFTQI 60
            |:.|||.|:.:|....||.::|.|||.:|.:. ..:|.:|          ||||||||||.||.|
  Rat    32 RVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDC-NTHDSLLQVCDDYSLEDNEYFFDRHPGAFTSI 95

  Fly    61 LNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKP 125
            ||:||||:||...::|...|.:||::||:|...:|.||.:.|...::..|     ::|..|.|..
  Rat    96 LNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMN-----EELKREAETL 155

  Fly   126 TEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKT 190
            .|.:       .|...|   .|....:.|:|.:.::|:||..|||:|.:|:.||.:|.|:..|.|
  Rat   156 RERE-------GEEFDN---TCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNT 210

  Fly   191 HPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSS 255
            .|..:      :.|..|.....|...|
  Rat   211 LPELQ------SLDEFGQSTDNPQLAH-------------------------------------- 231

  Fly   256 GNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYV 320
                                                                            |
  Rat   232 ----------------------------------------------------------------V 232

  Fly   321 ELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGLLE 377
            |.||..||.:|.::|.:.||..|:|.|.|:|.||..|.|.:|..:        :.:......:::
  Rat   233 EAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQ 297

  Fly   378 AFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQ 442
            .|.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |..|.:
  Rat   298 IFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDDTK 360

  Fly   443 FKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQA 507
            |||||...|||.:|||||||||:.|||..|..||.||.:||||.||||:|:||:|||.||.. |.
  Rat   361 FKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-QK 424

  Fly   508 RSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAGGPGLGGHAVG 572
            |.:...|||..|    .|.||.                        |.:|.:.
  Rat   425 RQEKAIKRREAL----ERAKRN------------------------GSIVSMN------------ 449

  Fly   573 HSAAGAPMFKDAFGGAKIGTVNV----NGVNVIGLHPAQRTTTTMAMAMNEADPTPMSALTYQVP 633
                    .|||| ...|..:::    ||.::......|
  Rat   450 --------MKDAF-ARSIEMMDIVVEKNGESIAKKDKVQ-------------------------- 479

  Fly   634 MLQPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASAAVATAAAAAP-AGPSFISSDYLS 697
                     .:|         |.|.....|..| |:.:::|.:..|....:| ...|..|..:|:
  Rat   480 ---------DNH---------LSPNKWKWTKRA-LSETSSSKSFETKEQGSPEKARSSSSPQHLN 525

  Fly   698 VPAVQSLQPRAATTGHDFMLPLQPKLLGPLERKDQHPLQLTAHNLASDTHQLMYSGHA----HSQ 758
            |..::.:..:.|.|....:  |..|.:.|   :.:.|.:|...::.|....|......    .|.
  Rat   526 VQQLEDMYSKMAKTQSQPI--LNTKEMAP---QSKPPEELEMSSMPSPVAPLPARTEGVIDMRSM 585

  Fly   759 HKVGGG-AAVLNVPPTLSMSHTQMPPGIASMGQRT-PNLSFRPAHGASSQVATVQQPIP------ 815
            ..:... :...:.|.....||:.:....:..|..| |.:.:|.|.|||....|...|||
  Rat   586 SSIDSFISCATDFPEATRFSHSPLASLSSKAGSSTAPEVGWRGALGASGGRLTETNPIPETSRSG 650

  Fly   816 ---HSHACHASTNCNIKISVASAGLSVGCPDEFRTPKVTLL----DDLSDDVNSSTDDCG-DCC- 871
               .|......||..:|:.........|.|    ||.:..|    |.|.:...::....| :|.
  Rat   651 FFVESPRSSMKTNNPLKLRALKVNFVEGDP----TPLLPSLGLYHDPLRNRGGAAAAVAGLECAS 711

  Fly   872 LVD------DSDTYEGTTINNGPSGQENGTE-AIGLDDGL---LDNDGEDE 912
            |:|      :|..|...:....|...|..|. |...:.|:   :|.|.:||
  Rat   712 LLDKPVLSPESSIYTTASARTPPRSPEKHTAIAFNFEAGVHHYIDTDTDDE 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	44/101 (44%)
		BTB_2	7..97	CDD:280393	43/99 (43%)
		Ion_trans	307..506	CDD:278921	92/206 (45%)
		Ion_trans_2	<449..499	CDD:285168	32/49 (65%)
Kcnb1	NP_037318.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		BTB_POZ_KCNB2	15..141	CDD:349719	47/109 (43%)
		Self-association. /evidence=ECO:0000269\|PubMed:18463252, ECO:0000269\|PubMed:19690160	59..75		3/16 (19%)
		Ion_trans	188..424	CDD:395416	108/346 (31%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	377..382		4/4 (100%)
		Self-association. /evidence=ECO:0000269\|PubMed:18463252, ECO:0000269\|PubMed:19690160	448..481		8/88 (9%)
		Kv2channel	467..678	CDD:397541	45/260 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..524		12/92 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..569		6/33 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..658		13/47 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	770..802
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810