DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shawl and Kcna2

DIOPT Version :10

Sequence 1:NP_001097131.2 Gene:Shawl / 5740840 FlyBaseID:FBgn0085395 Length:937 Species:Drosophila melanogaster
Sequence 2:NP_037102.1 Gene:Kcna2 / 25468 RGDID:2950 Length:499 Species:Rattus norvegicus


Alignment Length:510 Identity:169/510 - (33%)
Similarity:245/510 - (48%) Gaps:139/510 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69
            |:::|:||:|:||...||.:.|.|.|....:.:..:||:.|||||||:...|..||.||:: |:|
  Rat    34 RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 98

  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134
            ..|.:|...:|.||:.|:.|....:|        :.|:.:..:.       |.|:|..|      
  Rat    99 RRPVNVPLDIFSEEIRFYELGEEAME--------MFREDEGYIK-------EEERPLPE------ 142

  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199
                       |.:||   ::|.:|:.|.||..|:|:|.:||..|.:|::||||:|.|.||.:  
  Rat   143 -----------NEFQR---QVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDE-- 191

  Fly   200 SGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQA 264
              ..|.||.|.                 .:|.:|    :.:||         ...|.:||     
  Rat   192 --NEDMHGGGV-----------------TFHTYS----NSTIG---------YQQSTSFT----- 219

  Fly   265 TPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWFF 329
                                                              :.||.||.:|.:||.
  Rat   220 --------------------------------------------------DPFFIVETLCIIWFS 234

  Fly   330 IEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVMQRMGE------------YTGLLEAFSIV 382
            .|.::|....|:...|..:.:||||..|.:.::..:...:.|            ...:|....:|
  Rat   235 FEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLV 299

  Fly   383 RIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIP 447
            |:.|:|||:|||.||:||..|.|||.:||.||:|||.:|::.|:|..|:||  .|..|:||.|||
  Rat   300 RVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--ADERDSQFPSIP 362

  Fly   448 LGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFY 502
            ...|||:|:||||||||:.|.|..|..||:|||:|||||||||||||||||:.||
  Rat   363 DAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ShawlNP_001097131.2 BTB_Shaw-like 4..115 CDD:349723 37/109 (34%)
Ion_trans 307..506 CDD:459842 94/208 (45%)
Kcna2NP_037102.1 Tetramerization domain. /evidence=ECO:0000305|PubMed:11007484 1..125 36/98 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
BTB_POZ 33..159 CDD:453885 47/159 (30%)
Ion_trans 162..420 CDD:459842 120/347 (35%)
S4-S5 linker. /evidence=ECO:0000305|PubMed:16002579 312..325 7/12 (58%)
Selectivity filter. /evidence=ECO:0000305 374..379 4/4 (100%)
PDZ-binding. /evidence=ECO:0000269|PubMed:7477295 497..499
Blue background indicates that the domain is not in the aligned region.

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