DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shawl and Kcna1

DIOPT Version :9

Sequence 1:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_775118.1	Gene:	Kcna1 / 24520	RGDID:	2949	Length:	495	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	167/550 - (30%)
Similarity:	255/550 - (46%)	Gaps:	149/550 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFTQILNYYRT-GKL 69
            |:::|:||:|:||...||.:.|.|.|....:.:..:||:.|||||||:...|..||.||:: |:|
  Rat    38 RVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRL 102

  Fly    70 HYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIARLF 134
            ..|.:|...:|.||::|:.|....:|.        .|:.:..:.       |.|:|..|:.
  Rat   103 RRPVNVPLDMFSEEIKFYELGEEAMEK--------FREDEGFIK-------EEERPLPEKE---- 148

  Fly   135 GFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLP 199
                         :||   ::|.:|:.|.||..|:::|.:||..|.:|::.|||:|.|..:.|
  Rat   149 -------------YQR---QVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDD-- 195

  Fly   200 SGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYT-SYSSGNFTASGQ 263
                                                  ....|...|:.|.| .|:|..||
  Rat   196 --------------------------------------KDFTGTIHRIDNTTVIYTSNIFT---- 218

  Fly   264 ATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHEAFFYVELVCNVWF 328
                                                               :.||.||.:|.:||
  Rat   219 ---------------------------------------------------DPFFIVETLCIIWF 232

  Fly   329 FIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFY----TDVMQRMGEYTG-------LLEAFSIV 382
            ..|:::|....|:...|.|:.:|.||..|.:.::    |::.::.|...|       :|....:|
  Rat   233 SFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLV 297

  Fly   383 RIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDNQFKSIP 447
            |:.|:|||:|||.||:||..|.|||.:||.||:|||.:|::.|:|..|:||  .:..::.|.|||
  Rat   298 RVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE--AEEAESHFSSIP 360

  Fly   448 LGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLP 512
            ...|||:|:||||||||:.|.|..|..||:|||:|||||||||||||||||:.|| |.:...
  Rat   361 DAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFY-HRETEG--- 421

  Fly   513 KKRRRVLPVEQPRRKREPTAPHRGRTNAIK 542
            :::.::|.|..|....:.....|..:...|
  Rat   422 EEQAQLLHVSSPNLASDSDLSRRSSSTISK 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	35/92 (38%)
		BTB_2	7..97	CDD:280393	35/90 (39%)
		Ion_trans	307..506	CDD:278921	94/209 (45%)
		Ion_trans_2	<449..499	CDD:285168	36/49 (73%)
Kcna1	NP_775118.1	Tetramerization domain. /evidence=ECO:0000305	1..128		35/89 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		BTB_POZ	37..163	CDD:365784	46/159 (29%)
		Ion_trans	166..418	CDD:395416	114/349 (33%)
		S4-S5 linker. /evidence=ECO:0000250\|UniProtKB:P63142	310..323		7/12 (58%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:P63142	372..377		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000305	493..495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810